Naloxone blocks endomorphin-1 but not endomorphin-2 induced inhibition of tachykinergic contractions of guinea-pig isolated bronchus

Axel Fischer; Bradley J. Undem

doi:10.1038/sj.bjp.0702630

Naloxone blocks endomorphin-1 but not endomorphin-2 induced inhibition of tachykinergic contractions of guinea-pig isolated bronchus

Axel Fischer, Bradley J. Undem

School of Medicine

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The recently identified endogenous agonists on the μ-opioid-receptor (μOR), endomorphin-1 (EM-1) and endomorphin-2 (EM-2), induce a concentration dependent inhibition of electrical field stimulation (EFS)-induced tachykinin-mediated contractions of the guinea-pig bronchus (ED(50s) < 10 nM for both compounds). Surprisingly, only endomorphin-1 effects could be blocked by naloxone (10 μM), whereas endomorphin-2 effects were not affected by specific antagonists for the μ-, κ-, and δ-opioid-receptor.

Original language	English (US)
Pages (from-to)	605-608
Number of pages	4
Journal	British Journal of Pharmacology
Volume	127
Issue number	3
DOIs	https://doi.org/10.1038/sj.bjp.0702630
State	Published - 1999

Keywords

Endomorphin
Guinea-pig
Opioid receptors
Sensory nerves
Tachykinins

ASJC Scopus subject areas

Pharmacology

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10.1038/sj.bjp.0702630

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abstract = "The recently identified endogenous agonists on the μ-opioid-receptor (μOR), endomorphin-1 (EM-1) and endomorphin-2 (EM-2), induce a concentration dependent inhibition of electrical field stimulation (EFS)-induced tachykinin-mediated contractions of the guinea-pig bronchus (ED(50s) < 10 nM for both compounds). Surprisingly, only endomorphin-1 effects could be blocked by naloxone (10 μM), whereas endomorphin-2 effects were not affected by specific antagonists for the μ-, κ-, and δ-opioid-receptor.",

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AB - The recently identified endogenous agonists on the μ-opioid-receptor (μOR), endomorphin-1 (EM-1) and endomorphin-2 (EM-2), induce a concentration dependent inhibition of electrical field stimulation (EFS)-induced tachykinin-mediated contractions of the guinea-pig bronchus (ED(50s) < 10 nM for both compounds). Surprisingly, only endomorphin-1 effects could be blocked by naloxone (10 μM), whereas endomorphin-2 effects were not affected by specific antagonists for the μ-, κ-, and δ-opioid-receptor.

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KW - Sensory nerves

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Naloxone blocks endomorphin-1 but not endomorphin-2 induced inhibition of tachykinergic contractions of guinea-pig isolated bronchus

Abstract

Keywords

ASJC Scopus subject areas

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