N-Methyl-D-Aspartate Antagonist D-APV Selectively Disrupts Taste-Potentiated Odor Aversion Learning

Jeffrey Willner, Michela Gallagher, Phillip W. Graham, Geoffrey B. Crooks

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Two experiments examined the effects of the competitive N-methyl-D-aspartate (NMDA) antagonist D-APV (D-2-amino-5-phosphonovalerate) on rats' ability to acquire potentiated aversions to the odor element of a taste-odor compound. In Experiment 1, pretreatment with D-APV (2.5 μg/side icv) caused stereospecific deficits in potentiated odor aversion learning but left simple taste and odor aversion learning intact. In Experiment 2, pretreatment with D-APV had no effect on rats' acquisition of an illness-based odor discrimination task. These results parallel those previously obtained using a noncompetitive NMDA antagonist (Robinson, Crooks, Shinkman, & Gallagher, 1989) and show that interference with NMDA receptors can selectively impair potentiated odor aversion learning. These results suggest that NMDA receptors play a critical role in some, but not all, forms of learning and memory.

Original languageEnglish (US)
Pages (from-to)315-323
Number of pages9
JournalBehavioral Neuroscience
Issue number2
StatePublished - Apr 1992
Externally publishedYes

ASJC Scopus subject areas

  • Behavioral Neuroscience


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