Myxedema coma in a patient with Down's syndrome.

Darpan Bansal, Ashish Nanda, Ekta Gupta, Mary Croker, Misty L. Williams, Amy Bacchus, Debra Simmons, Marcia Erbland

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


INTRODUCTION: hyroid dysfunction is common in Down's syndrome, most common being hypothyroidism. Longstanding, untreated hypothyroidism can lead to myxedema coma. METHODS: Here we report a patient with Down's syndrome who presented with myxedema coma. DISCUSSION: The three essential elements for the diagnosis of myxedema coma include altered mental status, defective thermoregulation and a precipitating event or illness; all of these were present in our patient. Also, very high TSH, low T3 and T4, and the rapid response to the treatment with levothyroxine confirmed the diagnosis. CONCLUSION: Patients with Down's syndrome should have regular screening for thyroid dysfunction.

Original languageEnglish (US)
Pages (from-to)112-113
Number of pages2
JournalThe Journal of the Arkansas Medical Society
Issue number5
StatePublished - Nov 2006
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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