Myostatin and the control of skeletal muscle mass

Se Jin Lee, Alexandra C. McPherron

Research output: Contribution to journalComment/debatepeer-review

219 Scopus citations


The mechanisms by which tissue size is controlled are poorly understood. Over 30 years ago, Bullough proposed the existence of chalones, which act as tissue-specific negative growth regulators. The recent discovery of myostatin suggests that negative regulation of tissue growth may be an important mechanism for controlling skeletal muscle mass and raises the possibility that growth inhibitors may also be involved in regulating the size of other tissues.

Original languageEnglish (US)
Pages (from-to)604-607
Number of pages4
JournalCurrent Opinion in Genetics and Development
Issue number5
StatePublished - Oct 1 1999

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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