TY - JOUR
T1 - Myoglobin for Detection of High-Risk Patients with Acute Myocarditis
AU - Kottwitz, Jan
AU - Bruno, Katelyn A.
AU - Berg, Jan
AU - Salomon, Gary R.
AU - Fairweather, De Lisa
AU - Elhassan, Mawahib
AU - Baltensperger, Nora
AU - Kissel, Christine K.
AU - Lovrinovic, Marina
AU - Baltensweiler, Andrea
AU - Schmied, Christian
AU - Templin, Christian
AU - Lima, Joao A.C.
AU - Landmesser, Ulf
AU - Lüscher, Thomas F.
AU - Manka, Robert
AU - Heidecker, Bettina
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/10/1
Y1 - 2020/10/1
N2 - There is an unmet need for accurate and practical screening to detect myocarditis. We sought to test the hypothesis that the extent of acute myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), can be estimated based on routine blood markers. A total of 44 patients were diagnosed with acute myocarditis and included in this study. There was strong correlation between myoglobin and LGE (rs = 0.73 [95% CI 0.51; 0.87], p < 0.001), while correlation was weak between LGE and TnT-hs (rs = 0.37 [95% CI 0.09; 0.61], p = 0.01). Receiver operating curve (ROC) analysis determined myoglobin ≥ 87 μg/L as cutoff to identify myocarditis (92% sensitivity, 80% specificity). The data were reproduced in an established model of coxsackievirus B3 myocarditis in mice (n = 26). These data suggest that myoglobin is an accurate marker of acute myocarditis. [Figure not available: see fulltext.]
AB - There is an unmet need for accurate and practical screening to detect myocarditis. We sought to test the hypothesis that the extent of acute myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR), can be estimated based on routine blood markers. A total of 44 patients were diagnosed with acute myocarditis and included in this study. There was strong correlation between myoglobin and LGE (rs = 0.73 [95% CI 0.51; 0.87], p < 0.001), while correlation was weak between LGE and TnT-hs (rs = 0.37 [95% CI 0.09; 0.61], p = 0.01). Receiver operating curve (ROC) analysis determined myoglobin ≥ 87 μg/L as cutoff to identify myocarditis (92% sensitivity, 80% specificity). The data were reproduced in an established model of coxsackievirus B3 myocarditis in mice (n = 26). These data suggest that myoglobin is an accurate marker of acute myocarditis. [Figure not available: see fulltext.]
KW - Biomarker
KW - Cardiac enzymes
KW - Late gadolinium enhancement
KW - Magnetic resonance imaging
KW - Myocardial inflammation
KW - Myocarditis
KW - Myoglobin
KW - Troponin
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U2 - 10.1007/s12265-020-09957-8
DO - 10.1007/s12265-020-09957-8
M3 - Article
C2 - 32006209
AN - SCOPUS:85078895218
SN - 1937-5387
VL - 13
SP - 853
EP - 863
JO - Journal of cardiovascular translational research
JF - Journal of cardiovascular translational research
IS - 5
ER -