Abstract
Background: Myocilin, a secreted glaucoma-associated protein, is detected in the sciatic nerve, but its function there is not clear. Results: Myocilin null mutation leads to defects in the myelination of sciatic nerve acting through the ErbB2/ErbB3 receptor. Conclusion: Myocilin is a novel player in sciatic nerve myelination. Significance: This is the first demonstration of myocilin involvement in myelination.
Original language | English (US) |
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Pages (from-to) | 26357-26371 |
Number of pages | 15 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 37 |
DOIs | |
State | Published - Sep 13 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology