Myocarditis and Dilated Cardiomyopathy

Noel R. Rose, Ziya Kaya

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Myocarditis, inflammation of the heart muscle, is a prominent cause of heart failure, especially in children and young adults. It can be genetic in origin, the consequence of exposure to a drug or toxin, or a sequela of infection. The possible infectious agents include protozoa, bacteria, and viruses. A number of viruses have been implicated, especially enteroviruses and adenoviruses. During or following the infection, some individuals develop evidence of autoimmunity in the form of heart-specific antibodies and T cells. The autoimmune phase of the disease can be mimicked by direct immunization with cardiac antigens, including myosin heavy chain and troponin. The clinical diagnosis of myocarditis remains a challenge and definitive diagnosis often depends upon findings at autopsy or biopsy. Dilated cardiomyopathy is a chronic form of heart disease involving dilatation, especially of the left ventricle and often leading to congestive heart failure. It may be a sequela of myocarditis. The disease has a high case fatality rate. Investigations of the pathogenesis of viral and immune-mediated myocarditis and dilated cardiomyopathy have benefited from the development of experimental models in the mouse and rat. The disease can be reproduced in genetically selected hosts by infection with a cardiotropic virus or by immunization with an appropriate cardiac antigen.

Original languageEnglish (US)
Title of host publicationThe Autoimmune Diseases
Subtitle of host publicationFifth Edition
PublisherElsevier Inc.
Number of pages16
ISBN (Print)9780123849298
StatePublished - Dec 2013
Externally publishedYes


  • Beta adrenoreceptor
  • Cardiac myosin
  • Dilated cardiomyopathy
  • Endomyocardial biopsy
  • Heart failure
  • Myocarditis
  • Troponin

ASJC Scopus subject areas

  • General Immunology and Microbiology


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