Myocarditis and brain abscess caused by disseminated Scedosporium boydii infection

Devon L. Jackson, Lamarque Coke, Sean X. Zhang, Charles Steenbergen, Galam Khan, Gezahegn Gorfu, Roger A. Mitchell

Research output: Contribution to journalArticlepeer-review


Scedosporium spp. is a fungal species documented as the cause of infections involving the lungs, brain, and other organ systems in both immunocompetent and immunocompromised individuals. Many cases of this type of fungal infection occurring in immunocompetent patients are subsequent to traumatic injury or drowning events in or near waters containing the fungi. Infection commonly involves the lungs. Rarely, it has been shown to cause disease in the endocardium, but there is even less documentation of the fungi invading the myocardium and causing myocarditis. In this report, we present a case of disseminated Scedosporium boydii infection in a 52-year-old male patient without any known risk factors. He presented with acute onset chest pain and dyspnea accompanied by bilateral lower extremity edema. He was found to have new onset heart failure with reduced ejection fraction, and his hospital course was complicated by pneumonia, disseminated intravascular coagulation (DIC), and brain abscess formation. Multiple blood cultures failed to reveal the source of the infection. At autopsy, septated branching hyphae were identified invading both the myocardium and the cortical brain tissue. DNA sequencing revealed the fungal organisms to be Scedosporium boydii. This case reinforces the importance of autopsies in the clinical setting. It not only established the definitive diagnosis of an unexpected fungal infection, but it also helped to recognize new clinical and pathologic features of this particular fungal organism.

Original languageEnglish (US)
Pages (from-to)238-246
Number of pages9
JournalJournal of the National Medical Association
Issue number3
StatePublished - Jun 2024


  • Abscess
  • Autopsy
  • Brain
  • Diagnosis
  • Myocarditis
  • Scedosporium

ASJC Scopus subject areas

  • General Medicine


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