Myocardial T1 and extracellular volume fraction mapping at 3 tesla

Jason J. Lee, Songtao Liu, Marcelo S. Nacif, Martin Ugander, Jing Han, Nadine Kawel, Christopher T. Sibley, Peter Kellman, Andrew E. Arai, David A. Bluemke

Research output: Contribution to journalArticlepeer-review

123 Scopus citations


Background: To compare 11 heartbeat (HB) and 17 HB modified lock locker inversion recovery (MOLLI) pulse sequence at 3T and to establish preliminary reference values for myocardial T1 and the extracellular volume fraction (ECV). Methods. Both phantoms and normal volunteers were scanned at 3T using 11 HB and 17 HB MOLLI sequence with the following parameters: spatial resolution = 1.75 × 1.75 × 10 mm on a 256 × 180 matrix, TI initial = 110 ms, TI increment = 80 ms, flip angle = 35°, TR/TE = 1.9/1.0 ms. All volunteers were administered Gadolinium-DTPA (Magnevist, 0.15 mmol/kg), and multiple post-contrast MOLLI scans were performed at the same pre-contrast position from 3.5-23.5 minutes after a bolus contrast injection. Late gadolinium enhancement (LGE) images were also acquired 12-30 minutes after the gadolinium bolus. Results: T1 values of 11 HB and 17 HB MOLLI displayed good agreement in both phantom and volunteers. The average pre-contrast myocardial and blood T1 was 1315 39 ms and 2020 129 ms, respectively. ECV was stable between 8.5 to 23.5 minutes post contrast with an average of 26.7 1.0%. Conclusion: The 11 HB MOLLI is a faster method for high-resolution myocardial T1 mapping at 3T. ECV fractions are stable over a wide time range after contrast administration.

Original languageEnglish (US)
Article number75
JournalJournal of Cardiovascular Magnetic Resonance
Issue number1
StatePublished - 2011
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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