Inotropic alterations may alter contractile efficiency. Positive inotropic agents act mainly, if not exclusively, by increasing activation, which has very little effect on contractile efficiency. The metabolic effects of hypoxia may depress the contractile machinery directly. Acidosis is likely to decrease efficiency while an elevated phosphate, by itself, is likely to have little effect on efficiency.
|Number of pages
|Advances in Experimental Medicine and Biology
|Published - 1993
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)