Myocardial contrast echocardiography: Influence of ischaemia and hyperaemia in an animal model

S. A. Reisner, S. Gottlieb, A. Ernst, J. R. Shapiro, R. Beyar, W. Markiewicz, R. S. Meltzer

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


To evaluate changes in myocardial contrast echocardiography during ischaemia and hyperaemia, contrast studies were performed in 16 open chest dogs. Time-intensity curves were generated using videodensitometry after contrast injections to demonstrate ischaemic and non-ischaemic areas of interest during a wide range of coronary blood flow levels. For each time-intensity curve, the peak contrast intensity (PCI), washout halftime (T1/22) and area under the curve (AUC) were calculated. PCI and AUC decreased significantly only with severe ischaemia (90% or more reduction in flow), and increased significantly with hyperaemia of more than 2.5 times baseline flow. Both ischaemia and hyperaemia were found to prolong the T1/2. There was only a moderate linear correlation between the magnitude of hyperaemia and myocardial contrast echocardiographic parameters. There was significantly less increase in myocardial contrast echocardiographic parameters during hyperaemia in segments supplied by a stenosed coronary artery.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalEuropean Heart Journal
Issue number3
StatePublished - 1992
Externally publishedYes


  • Contrast echocardiography
  • Echocardiography
  • Hyperemia
  • Ischaemia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology


Dive into the research topics of 'Myocardial contrast echocardiography: Influence of ischaemia and hyperaemia in an animal model'. Together they form a unique fingerprint.

Cite this