TY - JOUR
T1 - Myeloperoxidase polymorphism and cognitive decline in older adults in the health, aging, and body composition study
AU - Pope, Sandra K.
AU - Kritchevsky, Stephen B.
AU - Ambrosone, Christine
AU - Yaffe, Kristine
AU - Tylavsky, Frances
AU - Simonsick, Eleanor M.
AU - Rosano, Caterina
AU - Stewart, Scott
AU - Harris, Tamara
N1 - Funding Information:
This study was supported by contracts N01-AG-6-2101, N01-AG-2103, and N01-AG-6-2106 from the National Institute on Aging (NIA). The research was supported in part by the Intramural Research Program of the National Institutes of Health, NIA. Dr. Pope’s research was funded by NIA grant K01-AG-20173, the Alzheimer’s Association, and the South Central Mental Illness Research, Education, Clinical Centers of the Central Arkansas Veterans Healthcare System. Conflict of interest: none declared.
PY - 2006/6
Y1 - 2006/6
N2 - Myeloperoxidase, an antimicrobial enzyme, produces oxidative free radicals. Rarely found in normal brain tissue, myeloperoxidase has been detected in microglia associated with Alzheimer's disease plaques. The authors examined a G-463A polymorphism in the promoter region of the myeloperoxidase gene (MPO) to determine the relation of MPO variants to cognitive decline over 4 years in a cohort of adults, aged 70-79 years at baseline (1997-1998), recruited from Memphis, Tennessee, and Pittsburgh, Pennsylvania, into the Health, Aging, and Body Composition Study. In this sample, 8% of the participants had the AA, 36.9% the AG, and 55.2% the GG genotype of MPO. The frequency of AA and AG genotypes was higher in Blacks than Whites (11.2% vs. 5.9%, and 44.1% vs. 32.9%, respectively). Multivariate logistic regression analyses showed that, for participants with the MPO AA genotype, cognitive decline was 1.58 (95% confidence interval: 1.07, 2.35) times more likely than for participants with the AG genotype and 1.96 (95% confidence interval: 1.33, 2.88) times more likely than for those with the GG genotype. Interactions between MPO and race, sex, or the apolipoprotein gene were not significant. In this sample, MPO AA, associated with decreased production of myeloperoxidase, was found to be a risk factor for cognitive decline.
AB - Myeloperoxidase, an antimicrobial enzyme, produces oxidative free radicals. Rarely found in normal brain tissue, myeloperoxidase has been detected in microglia associated with Alzheimer's disease plaques. The authors examined a G-463A polymorphism in the promoter region of the myeloperoxidase gene (MPO) to determine the relation of MPO variants to cognitive decline over 4 years in a cohort of adults, aged 70-79 years at baseline (1997-1998), recruited from Memphis, Tennessee, and Pittsburgh, Pennsylvania, into the Health, Aging, and Body Composition Study. In this sample, 8% of the participants had the AA, 36.9% the AG, and 55.2% the GG genotype of MPO. The frequency of AA and AG genotypes was higher in Blacks than Whites (11.2% vs. 5.9%, and 44.1% vs. 32.9%, respectively). Multivariate logistic regression analyses showed that, for participants with the MPO AA genotype, cognitive decline was 1.58 (95% confidence interval: 1.07, 2.35) times more likely than for participants with the AG genotype and 1.96 (95% confidence interval: 1.33, 2.88) times more likely than for those with the GG genotype. Interactions between MPO and race, sex, or the apolipoprotein gene were not significant. In this sample, MPO AA, associated with decreased production of myeloperoxidase, was found to be a risk factor for cognitive decline.
KW - Cognition
KW - Ethnic groups
KW - Peroxidase
KW - Polymorphism, genetic
KW - Prospective studies
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U2 - 10.1093/aje/kwj146
DO - 10.1093/aje/kwj146
M3 - Article
C2 - 16641309
AN - SCOPUS:33745625361
SN - 0002-9262
VL - 163
SP - 1084
EP - 1090
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 12
ER -