TY - JOUR
T1 - Myeloid cell diversification during regenerative inflammation
T2 - Lessons from skeletal muscle
AU - Patsalos, Andreas
AU - Tzerpos, Petros
AU - Wei, Xiaoyan
AU - Nagy, Laszlo
N1 - Funding Information:
L.N. is supported by the National Institutes of Health – National Institute of Diabetes and Digestive and Kidney Diseases ( R01-DK115924 , R01-DK124782 ). The Nuclear Receptor Research Laboratory at the University of Debrecen is supported by grants from the Hungarian Scientific Research Fund ( K124298 , K126885 , KKP129909 ).
Publisher Copyright:
© 2021 The Authors
PY - 2021/11
Y1 - 2021/11
N2 - Understanding the mechanisms of tissue and organ regeneration in adult animals and humans is of great interest from a basic biology as well as a medical, therapeutical point of view. It is increasingly clear that the relatively limited ability to regenerate tissues and organs in mammals as oppose to lower vertebrates is the consequence of evolutionary trade-offs and changes during development and aging. Thus, the coordinated interaction of the immune system, particularly the innate part of it, and the injured, degenerated parenchymal tissues such as skeletal muscle, liver, lung, or kidney shape physiological and also pathological processes. In this review, we provide an overview of how morphologically and functionally complete (ad integrum) regeneration is achieved using skeletal muscle as a model. We will review recent advances about the differentiation, activation, and subtype specification of circulating monocyte to resolution or repair-type macrophages during the process we term regenerative inflammation, resulting in complete restoration of skeletal muscle in murine models of toxin-induced injury.
AB - Understanding the mechanisms of tissue and organ regeneration in adult animals and humans is of great interest from a basic biology as well as a medical, therapeutical point of view. It is increasingly clear that the relatively limited ability to regenerate tissues and organs in mammals as oppose to lower vertebrates is the consequence of evolutionary trade-offs and changes during development and aging. Thus, the coordinated interaction of the immune system, particularly the innate part of it, and the injured, degenerated parenchymal tissues such as skeletal muscle, liver, lung, or kidney shape physiological and also pathological processes. In this review, we provide an overview of how morphologically and functionally complete (ad integrum) regeneration is achieved using skeletal muscle as a model. We will review recent advances about the differentiation, activation, and subtype specification of circulating monocyte to resolution or repair-type macrophages during the process we term regenerative inflammation, resulting in complete restoration of skeletal muscle in murine models of toxin-induced injury.
KW - Acute
KW - Macrophage
KW - Macrophage subtype specification
KW - Monocytes
KW - Muscle Regeneration
KW - Myeloid cells
KW - Regenerative inflammation
KW - Sterile injury
KW - Tissue repair
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U2 - 10.1016/j.semcdb.2021.05.005
DO - 10.1016/j.semcdb.2021.05.005
M3 - Review article
C2 - 34016524
AN - SCOPUS:85106208938
SN - 1084-9521
VL - 119
SP - 89
EP - 100
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -