Myelinated nociceptive afferents account for the hyperalgesia that follows a burn to the hand

R. A. Meyer; J. N. Campbell

doi:10.1126/science.7280675

Myelinated nociceptive afferents account for the hyperalgesia that follows a burn to the hand

R. A. Meyer, J. N. Campbell

School of Medicine

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164 Scopus citations

Abstract

Monkeys and human subjects were exposed to a series of thermal stimuli before and after a 53°C, 30-second burn to the glabrous skin of the hand. The responses of C- and A-fiber nociceptive afferents in the monkeys and subjective responses by the humans were compared. The burn resulted in increased sensitivity of the A fibers, decreased sensitivity of the C fibers, and increased pain sensibility (hyperalgesia) in the human subjects.

Original language	English (US)
Pages (from-to)	1527-1529
Number of pages	3
Journal	Science
Volume	213
Issue number	4515
DOIs	https://doi.org/10.1126/science.7280675
State	Published - 1981

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abstract = "Monkeys and human subjects were exposed to a series of thermal stimuli before and after a 53°C, 30-second burn to the glabrous skin of the hand. The responses of C- and A-fiber nociceptive afferents in the monkeys and subjective responses by the humans were compared. The burn resulted in increased sensitivity of the A fibers, decreased sensitivity of the C fibers, and increased pain sensibility (hyperalgesia) in the human subjects.",

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AB - Monkeys and human subjects were exposed to a series of thermal stimuli before and after a 53°C, 30-second burn to the glabrous skin of the hand. The responses of C- and A-fiber nociceptive afferents in the monkeys and subjective responses by the humans were compared. The burn resulted in increased sensitivity of the A fibers, decreased sensitivity of the C fibers, and increased pain sensibility (hyperalgesia) in the human subjects.

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Myelinated nociceptive afferents account for the hyperalgesia that follows a burn to the hand

Abstract

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