Mutations in CIC and FUBP1 contribute to human oligodendroglioma

Chetan Bettegowda; Nishant Agrawal; Yuchen Jiao; Mark Sausen; Laura D. Wood; Ralph H. Hruban; Fausto J. Rodriguez; Daniel P. Cahill; Roger McLendon; Gregory Riggins; Victor E. Velculescu; Sueli Mieko Oba-Shinjo; Suely Kazue Nagahashi Marie; Bert Vogelstein; Darell Bigner; Hai Yan; Nickolas Papadopoulos; Kenneth W. Kinzler

doi:10.1126/science.1210557

Mutations in CIC and FUBP1 contribute to human oligodendroglioma

Chetan Bettegowda, Nishant Agrawal, Yuchen Jiao, Mark Sausen, Laura D. Wood, Ralph H. Hruban, Fausto J. Rodriguez, Daniel P. Cahill, Roger McLendon, Gregory Riggins, Victor E. Velculescu, Sueli Mieko Oba-Shinjo, Suely Kazue Nagahashi Marie, Bert Vogelstein, Darell Bigner, Hai Yan, Nickolas Papadopoulos, Kenneth W. Kinzler

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Abstract

Oligodendrogliomas are the second most common malignant brain tumor in adults and exhibit characteristic losses of chromosomes 1p and 19q. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven tumors. Among other changes, we found that the CIC gene (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six cases and that the FUBP1 gene [encoding far-upstream element (FUSE) binding protein] on chromosome 1p was somatically mutated in two tumors. Examination of 27 additional oligodendrogliomas revealed 12 and 3 more tumors with mutations of CIC and FUBP1, respectively, 58% of which were predicted to result in truncations of the encoded proteins. These results suggest a critical role for these genes in the biology and pathology of oligodendrocytes.

Original language	English (US)
Pages (from-to)	1453-1455
Number of pages	3
Journal	Science
Volume	333
Issue number	6048
DOIs	https://doi.org/10.1126/science.1210557
State	Published - Sep 9 2011

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Bettegowda, C., Agrawal, N., Jiao, Y., Sausen, M., Wood, L. D., Hruban, R. H., Rodriguez, F. J., Cahill, D. P., McLendon, R., Riggins, G., Velculescu, V. E., Oba-Shinjo, S. M., Marie, S. K. N., Vogelstein, B., Bigner, D., Yan, H., Papadopoulos, N., & Kinzler, K. W. (2011). Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science, 333(6048), 1453-1455. https://doi.org/10.1126/science.1210557

Bettegowda, C, Agrawal, N, Jiao, Y, Sausen, M, Wood, LD , Hruban, RH, Rodriguez, FJ, Cahill, DP, McLendon, R, Riggins, G , Velculescu, VE, Oba-Shinjo, SM, Marie, SKN, Vogelstein, B, Bigner, D, Yan, H, Papadopoulos, N & Kinzler, KW 2011, 'Mutations in CIC and FUBP1 contribute to human oligodendroglioma', Science, vol. 333, no. 6048, pp. 1453-1455. https://doi.org/10.1126/science.1210557

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title = "Mutations in CIC and FUBP1 contribute to human oligodendroglioma",

abstract = "Oligodendrogliomas are the second most common malignant brain tumor in adults and exhibit characteristic losses of chromosomes 1p and 19q. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven tumors. Among other changes, we found that the CIC gene (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six cases and that the FUBP1 gene [encoding far-upstream element (FUSE) binding protein] on chromosome 1p was somatically mutated in two tumors. Examination of 27 additional oligodendrogliomas revealed 12 and 3 more tumors with mutations of CIC and FUBP1, respectively, 58% of which were predicted to result in truncations of the encoded proteins. These results suggest a critical role for these genes in the biology and pathology of oligodendrocytes.",

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AU - Hruban, Ralph H.

AU - Rodriguez, Fausto J.

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AU - McLendon, Roger

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AU - Velculescu, Victor E.

AU - Oba-Shinjo, Sueli Mieko

AU - Marie, Suely Kazue Nagahashi

AU - Vogelstein, Bert

AU - Bigner, Darell

AU - Yan, Hai

AU - Papadopoulos, Nickolas

AU - Kinzler, Kenneth W.

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Mutations in CIC and FUBP1 contribute to human oligodendroglioma

Abstract

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