Abstract
Amino acid substitutions were introduced into four conserved N-linked glycosylation sites of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein, gp41, to alter the canonical N-linked glycosylation sequences. One altered site produced a severe impairment of viral infectivity, which raises the possibility that N-linked sugars at this site may have an important role in the human immunodeficiency virus type 1 life cycle.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1799-1803 |
| Number of pages | 5 |
| Journal | Journal of virology |
| Volume | 66 |
| Issue number | 3 |
| State | Published - Mar 1992 |
| Externally published | Yes |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology