Muscular effects of statins in the elderly female: A review

Shilpa Bhardwaj, Shalini Selvarajah, Eric B. Schneider

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Statins have demonstrated substantial benefits in supporting cardiovascular health. Older individuals are more likely to experience the well-known muscle-related side effects of statins compared with younger individuals. Elderly females may be especially vulnerable to statin-related muscle disorder. This review will collate and discuss statin-related muscular effects, examine their molecular and genetic basis, and how these apply specifically to elderly women. Developing strategies to reduce the incidence of statin-induced myopathy in older adult women could contribute to a significant reduction in the overall incidence of statin-induced muscle disorder in this vulnerable group of patients. Reducing statin-related muscle disorder would likely improve overall patient compliance, thereby leading to an increase in improved short- and long-term outcomes associated with appropriate use of statins.

Original languageEnglish (US)
Pages (from-to)47-59
Number of pages13
JournalClinical Interventions in Aging
StatePublished - 2013


  • Elderly
  • Epidemiology
  • Females
  • Older adults
  • Statins

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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