Muscle pouch implantation: An ectopic bone formation model

Greg Asatrian; Le Chang; Aaron W. James

doi:10.1007/978-1-4939-1453-1_15

Muscle pouch implantation: An ectopic bone formation model

Greg Asatrian, Le Chang, Aaron W. James

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Ectopic bone formation refers to the ossification of tissue outside of its typical microenvironment. Numerous animal models exist to experimentally induce ectopic bone formation in order to examine the process of osteogenesis or to evaluate the “osteogenic potential” of a given implant. The most widely employed methods in the rodent include subcutaneous, intramuscular, and renal capsule implantation. This chapter will outline the (1) clinical correlates to ectopic ossification, (2) a brief history of experimental models of ectopic ossification, (3) advantages and disadvantages of various models (with a focus on rodent models), and (4) detailed methods and explanation of a mouse intramuscular implantation procedure.

Original language	English (US)
Pages (from-to)	185-191
Number of pages	7
Journal	Methods in Molecular Biology
Volume	1213
DOIs	https://doi.org/10.1007/978-1-4939-1453-1_15
State	Published - 2014
Externally published	Yes

Keywords

Bone
Ectopic
Graft
Heterotopic
Model
Muscle pouch implantation

ASJC Scopus subject areas

Molecular Biology
Genetics

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title = "Muscle pouch implantation: An ectopic bone formation model",

abstract = "Ectopic bone formation refers to the ossification of tissue outside of its typical microenvironment. Numerous animal models exist to experimentally induce ectopic bone formation in order to examine the process of osteogenesis or to evaluate the “osteogenic potential” of a given implant. The most widely employed methods in the rodent include subcutaneous, intramuscular, and renal capsule implantation. This chapter will outline the (1) clinical correlates to ectopic ossification, (2) a brief history of experimental models of ectopic ossification, (3) advantages and disadvantages of various models (with a focus on rodent models), and (4) detailed methods and explanation of a mouse intramuscular implantation procedure.",

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AU - Asatrian, Greg

AU - Chang, Le

AU - James, Aaron W.

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N2 - Ectopic bone formation refers to the ossification of tissue outside of its typical microenvironment. Numerous animal models exist to experimentally induce ectopic bone formation in order to examine the process of osteogenesis or to evaluate the “osteogenic potential” of a given implant. The most widely employed methods in the rodent include subcutaneous, intramuscular, and renal capsule implantation. This chapter will outline the (1) clinical correlates to ectopic ossification, (2) a brief history of experimental models of ectopic ossification, (3) advantages and disadvantages of various models (with a focus on rodent models), and (4) detailed methods and explanation of a mouse intramuscular implantation procedure.

AB - Ectopic bone formation refers to the ossification of tissue outside of its typical microenvironment. Numerous animal models exist to experimentally induce ectopic bone formation in order to examine the process of osteogenesis or to evaluate the “osteogenic potential” of a given implant. The most widely employed methods in the rodent include subcutaneous, intramuscular, and renal capsule implantation. This chapter will outline the (1) clinical correlates to ectopic ossification, (2) a brief history of experimental models of ectopic ossification, (3) advantages and disadvantages of various models (with a focus on rodent models), and (4) detailed methods and explanation of a mouse intramuscular implantation procedure.

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KW - Model

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ER -

Muscle pouch implantation: An ectopic bone formation model

Abstract

Keywords

ASJC Scopus subject areas

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