TY - JOUR
T1 - Multivariable Analyses of Amblyopia Treatment Outcomes from a Clinical Data Registry
AU - Repka, Michael X.
AU - Li, Charles
AU - Lum, Flora
N1 - Publisher Copyright:
© 2022 American Academy of Ophthalmology
PY - 2023/2
Y1 - 2023/2
N2 - Purpose: To present multivariable analyses of factors associated with amblyopia treatment success using outcomes from a clinical registry. Design: Retrospective database study. Participants: New patients 3 to 12 years of age being enrolled in the registry from 2013 to 2019. Main Outcome Measure: The IRIS-50 is an outcome measure for amblyopia treatment developed by the American Academy of Ophthalmology for use with data in the Intelligent Research in Sight (IRIS®) Registry. The measure specifications include unilateral amblyopia associated with strabismus, refractive error, or both. Methods: Clinical care prescribed by the ophthalmologist. Results: Eighteen thousand eight hundred forty-one children 3 to 7 years of age were eligible for IRIS-50, with 77.3% successful. Nine thousand seven hundred sixty-two children 8 to 12 years of age were eligible, with 55.5% successful. For the younger age group, multivariable analyses found that odds ratios (ORs) for success were significantly lower for Black children (0.71; 95% confidence interval [CI], 0.62–0.83) compared with White children. Medicaid insurance was associated independently with significantly lower success (OR, 0.65; 95% CI, 0.60–0.71). Among older children, Black children were less likely to be treated successfully (OR, 0.81; 95% CI, 0.68–0.96) compared with White children, whereas Hispanic children showed an increased chance of success (OR, 1.16; 95% CI, 1.03–1.31). Medicaid insurance for the older children also was associated with a decreased chance of success (OR, 0.84; 95% CI, 0.77–0.93). Conclusions: Amblyopia treatment outcomes measured by IRIS-50 were significantly poorer for Black children and those with Medicaid insurance 3 to 12 years of age. Disparate health outcomes demonstrated for these two factors emphasize the need to develop and test strategies to improve treatment outcomes for these children.
AB - Purpose: To present multivariable analyses of factors associated with amblyopia treatment success using outcomes from a clinical registry. Design: Retrospective database study. Participants: New patients 3 to 12 years of age being enrolled in the registry from 2013 to 2019. Main Outcome Measure: The IRIS-50 is an outcome measure for amblyopia treatment developed by the American Academy of Ophthalmology for use with data in the Intelligent Research in Sight (IRIS®) Registry. The measure specifications include unilateral amblyopia associated with strabismus, refractive error, or both. Methods: Clinical care prescribed by the ophthalmologist. Results: Eighteen thousand eight hundred forty-one children 3 to 7 years of age were eligible for IRIS-50, with 77.3% successful. Nine thousand seven hundred sixty-two children 8 to 12 years of age were eligible, with 55.5% successful. For the younger age group, multivariable analyses found that odds ratios (ORs) for success were significantly lower for Black children (0.71; 95% confidence interval [CI], 0.62–0.83) compared with White children. Medicaid insurance was associated independently with significantly lower success (OR, 0.65; 95% CI, 0.60–0.71). Among older children, Black children were less likely to be treated successfully (OR, 0.81; 95% CI, 0.68–0.96) compared with White children, whereas Hispanic children showed an increased chance of success (OR, 1.16; 95% CI, 1.03–1.31). Medicaid insurance for the older children also was associated with a decreased chance of success (OR, 0.84; 95% CI, 0.77–0.93). Conclusions: Amblyopia treatment outcomes measured by IRIS-50 were significantly poorer for Black children and those with Medicaid insurance 3 to 12 years of age. Disparate health outcomes demonstrated for these two factors emphasize the need to develop and test strategies to improve treatment outcomes for these children.
KW - Amblyopia
KW - Clinical data registry
KW - Health care disparity
KW - Treatment outcome
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U2 - 10.1016/j.ophtha.2022.09.005
DO - 10.1016/j.ophtha.2022.09.005
M3 - Article
C2 - 36100075
AN - SCOPUS:85140641133
SN - 0161-6420
VL - 130
SP - 164
EP - 166
JO - Ophthalmology
JF - Ophthalmology
IS - 2
ER -