Multivariable Analyses of Amblyopia Treatment Outcomes from a Clinical Data Registry

Michael X. Repka, Charles Li, Flora Lum

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To present multivariable analyses of factors associated with amblyopia treatment success using outcomes from a clinical registry. Design: Retrospective database study. Participants: New patients 3 to 12 years of age being enrolled in the registry from 2013 to 2019. Main Outcome Measure: The IRIS-50 is an outcome measure for amblyopia treatment developed by the American Academy of Ophthalmology for use with data in the Intelligent Research in Sight (IRIS®) Registry. The measure specifications include unilateral amblyopia associated with strabismus, refractive error, or both. Methods: Clinical care prescribed by the ophthalmologist. Results: Eighteen thousand eight hundred forty-one children 3 to 7 years of age were eligible for IRIS-50, with 77.3% successful. Nine thousand seven hundred sixty-two children 8 to 12 years of age were eligible, with 55.5% successful. For the younger age group, multivariable analyses found that odds ratios (ORs) for success were significantly lower for Black children (0.71; 95% confidence interval [CI], 0.62–0.83) compared with White children. Medicaid insurance was associated independently with significantly lower success (OR, 0.65; 95% CI, 0.60–0.71). Among older children, Black children were less likely to be treated successfully (OR, 0.81; 95% CI, 0.68–0.96) compared with White children, whereas Hispanic children showed an increased chance of success (OR, 1.16; 95% CI, 1.03–1.31). Medicaid insurance for the older children also was associated with a decreased chance of success (OR, 0.84; 95% CI, 0.77–0.93). Conclusions: Amblyopia treatment outcomes measured by IRIS-50 were significantly poorer for Black children and those with Medicaid insurance 3 to 12 years of age. Disparate health outcomes demonstrated for these two factors emphasize the need to develop and test strategies to improve treatment outcomes for these children.

Original languageEnglish (US)
Pages (from-to)164-166
Number of pages3
JournalOphthalmology
Volume130
Issue number2
DOIs
StatePublished - Feb 2023

Keywords

  • Amblyopia
  • Clinical data registry
  • Health care disparity
  • Treatment outcome

ASJC Scopus subject areas

  • Ophthalmology

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