Multistage evaluation of measurement error in a reliability study

Aiyi Liu, Enrique F. Schisterman, Chengqing Wu

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


We introduce sequential testing procedures for the planning and analysis of reliability studies to assess an exposure's measurement error. The designs allow repeated evaluation of reliability of the measurements and stop testing if early evidence shows the measurement error is within the level of tolerance. Methods are developed and critical values tabulated for a number of two-stage designs. The methods are exemplified using an example evaluating the reliability of biomarkers associated with oxidative stress.

Original languageEnglish (US)
Pages (from-to)1190-1196
Number of pages7
Issue number4
StatePublished - Dec 2006
Externally publishedYes


  • Interim analysis
  • Intraclass correlation
  • Measurement error
  • Power and sample size

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Applied Mathematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Statistics and Probability


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