Multiregional age-associated reduction of brain neuronal reserve without association with neurofibrillary degeneration or β-amyloidosis

Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Shuang Yong Ma, Jarek Wegiel, Eulalia Badmaev, Wayne P. Silverman, Mony de Leon, Barry Reisberg, Thomas Wisniewski

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Increase in human life expectancy has resulted in the rapid growth of the elderly population with minimal or no intellectual deterioration. The aim of this stereological study of 10 structures and 5 subdivisions with and without neurofibrillary degeneration in the brains of 28 individuals 25-102-years-old was to establish the pattern of age-associated neurodegeneration and neuronal loss in the brains of nondemented adults and elderly. The study revealed the absence of significant neuronal loss in 7 regions and topographically selective reduction of neuronal reserve over 77 years in 8 brain structures including the entorhinal cortex (EC) (-33.3%), the second layer of the EC (-54%), cornu Ammonis sector 1 (CA1) (-28.5%), amygdala, (-45.8%), thalamus (-40.5%), caudate nucleus (-35%), Purkinje cells (-48.3%), and neurons in the dentate nucleus (40.1%). A similar rate of neuronal loss in adults and elderly, without signs of accelerating neuronal loss in agers or super-agers, appears to indicate age-associated brain remodeling with significant reduction of neuronal reserve in 8 brain regions. Multivariate analysis demonstrates the absence of a significant association between neuronal loss and the severity of neurofibrillary degeneration and b-amyloidosis, and a similar rate of age-associated neuronal loss in structures with and without neurofibrillary degeneration.

Original languageEnglish (US)
Pages (from-to)439-457
Number of pages19
JournalJournal of neuropathology and experimental neurology
Issue number6
StatePublished - Jun 1 2017


  • Brain aging
  • Neurofibrillary degeneration
  • Neuronal loss
  • Neuronal reserve
  • β-Amyloidosis

ASJC Scopus subject areas

  • General Medicine


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