Multipoint gene mapping using seriation. I. General methods

K. H. Buetow, A. Chakravarti

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Initial and accurate inference of locus order and estimates of interlocus distances and interference can be obtained using seriation techniques. The analysis requires a matrix of recombination values that can be estimated by standard pairwise linkage analysis. This allows combination of results from individual investigators without reanalysis of basic pedigree material. Seriation can be performed without the use of a computer.

Original languageEnglish (US)
Pages (from-to)180-188
Number of pages9
JournalAmerican journal of human genetics
Issue number2
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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