Multiple subpial transection for intractable partial epilepsy: An international meta-analysis

Susan S. Spencer, Johannes Schramm, Allen Wyler, Michael O'Connor, Darren Orbach, Gregory Krauss, Michael Sperling, Orrin Devinsky, Christian Elger, Ronald Lesser, Lisa Mulligan, Michael Westerveld

Research output: Contribution to journalArticlepeer-review

127 Scopus citations


Purpose: Because the number and variety of patients at any single facility is not sufficient for clinical or statistical analysis, data from six major epilepsy centers that performed multiple subpial transections (MSTs) for medically intractable epilepsy were collected. Methods: A meta-analysis was performed to elucidate the indications and outcome, and to assess the results of the procedure. Overall, 211 patients were represented with data regarding preoperative evaluation, procedures, seizure types and frequencies before and after surgery, postoperative deficits, and demographic information. Fifty-three patients underwent MST without resection. Results: In patients with MST plus resection, excellent outcome (<95% reduction in seizure frequency) was obtained in 87% of patients for generalized seizures, 68% for complex partial seizures, and 68% for simple partial seizures. For the patients who underwent MST without resection, the rate of excellent outcome was only slightly lower, at 71% for generalized, 62% for complex partial, and 63% for simple partial seizures. EEG localization, age at epilepsy onset, duration of epilepsy, and location of MST were not significant predictors of outcome for any kinds of seizures after MST, with or without resection. New neurologic deficits were found in 47 patients overall, comparable in MST with resection (23%) or without (19%). Conclusions: These preliminary results suggest that MST has efficacy by itself, with minimal neurologic compromise, in cases in which resective surgery cannot be used to treat uncontrolled epilepsy. MST should be investigated as a stand-alone procedure to allow further development of criteria and predictive factors for outcome.

Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
Issue number2
StatePublished - 2002


  • Epilepsy surgery
  • MST
  • Multiple subpial transection
  • Refractory epilepsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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