Multiple roles for emerin: Implications for Emery-Dreifuss muscular dystrophy

James M. Holaska, Katherine L. Wilson

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) is inherited through mutations in EMD, which encodes a nuclear membrane protein named emerin. Emerin is expressed in most cells, but EDMD strikes specific tissues. This review summarizes growing evidence that emerin has roles in both tissue-specific gene regulation and the mechanical integrity of the nucleus and discusses how these roles might impact EDMD.

Original languageEnglish (US)
Pages (from-to)676-680
Number of pages5
JournalAnatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
Issue number7
StatePublished - Jul 2006


  • Emery-Dreifuss muscular dystrophy
  • Lamin
  • Laminopathy
  • Nuclear envelope

ASJC Scopus subject areas

  • Anatomy
  • Agricultural and Biological Sciences (miscellaneous)


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