TY - JOUR
T1 - Multiple biologic activities of a cloned inducer T-cell population
AU - Nabel, G.
AU - Greenberger, J. S.
AU - Sakakeeny, M. A.
AU - Cantor, H.
PY - 1981
Y1 - 1981
N2 - The mouse T-cell clone Ly1+2-/9, belonging to the Ly1 set, displays the following functions in vitro: (i) augmentation of immunoglobulin output by B cells; (ii) stimulation of bone marrow cells to produce colonies composed of granulocytes, macrophages, or both; and (iii) proliferative stimulation of T-cell clones belonging to other Ly sets. These functions are induced by Ly1+2-/9 cells themselves and by supernatants of Ly1+2-/9 cultures and are not evinced by tested clones belonging to other Ly sets. The agent or agents responsible for colony formation and for B-cell stimulation had an apparent molecular weight of 45,000-50,000 and could not be physically separated. The T-cell stimulating agents(s) had an apparent molecular weight of 30,000 and could be separated from the agent(s) that acts upon colony formation and B cells. Thus, clone Ly1+2-/9 produces at least two soluble products that induce or augment activities of at least three other differently programmed cell sets.
AB - The mouse T-cell clone Ly1+2-/9, belonging to the Ly1 set, displays the following functions in vitro: (i) augmentation of immunoglobulin output by B cells; (ii) stimulation of bone marrow cells to produce colonies composed of granulocytes, macrophages, or both; and (iii) proliferative stimulation of T-cell clones belonging to other Ly sets. These functions are induced by Ly1+2-/9 cells themselves and by supernatants of Ly1+2-/9 cultures and are not evinced by tested clones belonging to other Ly sets. The agent or agents responsible for colony formation and for B-cell stimulation had an apparent molecular weight of 45,000-50,000 and could not be physically separated. The T-cell stimulating agents(s) had an apparent molecular weight of 30,000 and could be separated from the agent(s) that acts upon colony formation and B cells. Thus, clone Ly1+2-/9 produces at least two soluble products that induce or augment activities of at least three other differently programmed cell sets.
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M3 - Article
C2 - 6785749
AN - SCOPUS:0019499067
SN - 0027-8424
VL - 78
SP - 1157
EP - 1161
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 2 II
ER -