Multiple and surprising new functions for emerin, a nuclear membrane protein

Luiza Bengtsson; Katherine L. Wilson

doi:10.1016/j.ceb.2003.11.012

Multiple and surprising new functions for emerin, a nuclear membrane protein

Luiza Bengtsson, Katherine L. Wilson

School of Medicine

Research output: Contribution to journal › Review article › peer-review

106 Scopus citations

Abstract

Emerin is an integral protein of the nuclear inner membrane. Emerin is not essential, but its loss of function causes Emery-Dreifuss muscular dystrophy. We summarize significant recent progress in understanding emerin, which was previously known to interact with barrier-to-autointegration factor and lamins. New partners include transcription repressors, an mRNA splicing regulator, a nuclear membrane protein named nesprin, nuclear myosin I and F-actin. These interactors imply multiple roles for emerin in the nucleus, some of which overlap with related LEM-domain proteins.

Original language	English (US)
Pages (from-to)	73-79
Number of pages	7
Journal	Current Opinion in Cell Biology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/j.ceb.2003.11.012
State	Published - Feb 2004

Keywords

(nuclear) inner membrane
BAF
Barrier-to-autointegration factor
EDMD
Emery-Dreifuss muscular dystrophy
FRAP
Fluorescence recovery after photobleaching
GCL
Germ-cell-less
IM
LEM-domain
MEF
∼40-residue folded motif shared by LAP2, emerin and MAN1

ASJC Scopus subject areas

Cell Biology

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10.1016/j.ceb.2003.11.012

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@article{1feffefa082047058b858ac006329f1e,

title = "Multiple and surprising new functions for emerin, a nuclear membrane protein",

abstract = "Emerin is an integral protein of the nuclear inner membrane. Emerin is not essential, but its loss of function causes Emery-Dreifuss muscular dystrophy. We summarize significant recent progress in understanding emerin, which was previously known to interact with barrier-to-autointegration factor and lamins. New partners include transcription repressors, an mRNA splicing regulator, a nuclear membrane protein named nesprin, nuclear myosin I and F-actin. These interactors imply multiple roles for emerin in the nucleus, some of which overlap with related LEM-domain proteins.",

keywords = "(nuclear) inner membrane, BAF, Barrier-to-autointegration factor, EDMD, Emery-Dreifuss muscular dystrophy, FRAP, Fluorescence recovery after photobleaching, GCL, Germ-cell-less, IM, LEM-domain, MEF, ∼40-residue folded motif shared by LAP2, emerin and MAN1",

author = "Luiza Bengtsson and Wilson, {Katherine L.}",

note = "Funding Information: We thank collegues who shared unpublished manuscripts and helped to make this review timely. Warmest thanks to members of the Wilson laboratory for useful comments on the manuscript. LB is supported by the Deutsche Forschungsgemeinschaft. KLW gratefully acknowledges support from the Mills family, and the Scott B. Deutschman Memorial Research Award of the American Heart Association.",

year = "2004",

month = feb,

doi = "10.1016/j.ceb.2003.11.012",

language = "English (US)",

volume = "16",

pages = "73--79",

journal = "Current Opinion in Cell Biology",

issn = "0955-0674",

publisher = "Elsevier Limited",

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T1 - Multiple and surprising new functions for emerin, a nuclear membrane protein

AU - Bengtsson, Luiza

AU - Wilson, Katherine L.

N1 - Funding Information: We thank collegues who shared unpublished manuscripts and helped to make this review timely. Warmest thanks to members of the Wilson laboratory for useful comments on the manuscript. LB is supported by the Deutsche Forschungsgemeinschaft. KLW gratefully acknowledges support from the Mills family, and the Scott B. Deutschman Memorial Research Award of the American Heart Association.

PY - 2004/2

Y1 - 2004/2

N2 - Emerin is an integral protein of the nuclear inner membrane. Emerin is not essential, but its loss of function causes Emery-Dreifuss muscular dystrophy. We summarize significant recent progress in understanding emerin, which was previously known to interact with barrier-to-autointegration factor and lamins. New partners include transcription repressors, an mRNA splicing regulator, a nuclear membrane protein named nesprin, nuclear myosin I and F-actin. These interactors imply multiple roles for emerin in the nucleus, some of which overlap with related LEM-domain proteins.

AB - Emerin is an integral protein of the nuclear inner membrane. Emerin is not essential, but its loss of function causes Emery-Dreifuss muscular dystrophy. We summarize significant recent progress in understanding emerin, which was previously known to interact with barrier-to-autointegration factor and lamins. New partners include transcription repressors, an mRNA splicing regulator, a nuclear membrane protein named nesprin, nuclear myosin I and F-actin. These interactors imply multiple roles for emerin in the nucleus, some of which overlap with related LEM-domain proteins.

KW - (nuclear) inner membrane

KW - BAF

KW - Barrier-to-autointegration factor

KW - EDMD

KW - Emery-Dreifuss muscular dystrophy

KW - FRAP

KW - Fluorescence recovery after photobleaching

KW - GCL

KW - Germ-cell-less

KW - IM

KW - LEM-domain

KW - MEF

KW - ∼40-residue folded motif shared by LAP2, emerin and MAN1

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U2 - 10.1016/j.ceb.2003.11.012

DO - 10.1016/j.ceb.2003.11.012

M3 - Review article

C2 - 15037308

AN - SCOPUS:1542382269

SN - 0955-0674

VL - 16

SP - 73

EP - 79

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 1

ER -

Multiple and surprising new functions for emerin, a nuclear membrane protein

Abstract

Keywords

ASJC Scopus subject areas

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