Abstract
The potent excitatory amino acid receptor agonist, N-methyl-d-aspartate (NMDA), was applied to cat neocortical neurons in an in vitro slice preparation. NMDA evokes a slow depolarization with a net input conductance decrease, repetitive firing, rhythmic depolarization shifts and bi-stable membrane potential behavior. Use of blocking agents, ion substitution and voltage clamp indicates that NMDA induces a highly voltage-dependent TTX-resistant inward sodium current which accounts for much of the NMDA response.
Original language | English (US) |
---|---|
Pages (from-to) | 169-173 |
Number of pages | 5 |
Journal | Brain research |
Volume | 266 |
Issue number | 1 |
DOIs | |
State | Published - Apr 25 1983 |
Externally published | Yes |
Keywords
- N-methyl-d-aspartate
- depolarization shift
- inward rectification
- neocortical neurons
- transmitter-sensitive conductance
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology