Multiple actions of N-methyl-d-aspartate on cat neocortical neurons in vitro

J. A. Flatman, P. C. Schwindt, W. E. Crill, C. E. Stafstrom

Research output: Contribution to journalArticlepeer-review

130 Scopus citations


The potent excitatory amino acid receptor agonist, N-methyl-d-aspartate (NMDA), was applied to cat neocortical neurons in an in vitro slice preparation. NMDA evokes a slow depolarization with a net input conductance decrease, repetitive firing, rhythmic depolarization shifts and bi-stable membrane potential behavior. Use of blocking agents, ion substitution and voltage clamp indicates that NMDA induces a highly voltage-dependent TTX-resistant inward sodium current which accounts for much of the NMDA response.

Original languageEnglish (US)
Pages (from-to)169-173
Number of pages5
JournalBrain research
Issue number1
StatePublished - Apr 25 1983
Externally publishedYes


  • N-methyl-d-aspartate
  • depolarization shift
  • inward rectification
  • neocortical neurons
  • transmitter-sensitive conductance

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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