Multiparametric and multinuclear magnetic resonance imaging of human breast cancer: Current applications

Michael A. Jacobs, Ronald Ouwerkerk, Antonio C. Wolff, Vered Stearns, Paul A. Bottomley, Peter B. Barker, Pedram Argani, Nagi Khouri, Nancy E. Davidson, Zaver M. Bhujwalla, David A. Bluemke

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


The exploration of novel imaging methods that have the potential to improve specificity for the identification of malignancy is still critically needed in breast imaging. Changes in physiologic alterations of soft tissue water associated with breast cancer can be visualized by magnetic resonance (MR) imaging. However, it is unlikely that a single MR parameter can characterize the complexity of breast tissue. Techniques such as multiparametric MR imaging, proton magnetic resonance spectroscopic (MRSI) imaging, and 23Na sodium MR imaging when used in combination provide a comprehensive data set with potentially more power to diagnose breast disease than any single measure alone. A combination of MR, MRSI, and 23Na sodium MR parameters may be examined in a single MR imaging examination, potentially resulting in improved specificity for radiologic evaluation of malignancy.

Original languageEnglish (US)
Pages (from-to)543-550
Number of pages8
JournalTechnology in Cancer Research and Treatment
Issue number6
StatePublished - Dec 2004


  • Breast
  • Cancer
  • Diffusion
  • Magnetic Resonance Imaging
  • NA
  • Neoplasm
  • Proton
  • Sodium MR
  • Spectroscopy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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