Multifunctional microrobot with real-time visualization and magnetic resonance imaging for chemoembolization therapy of liver cancer

Gwangjun Go, Ami Yoo, Kim Tien Nguyen, Minghui Nan, Bobby Aditya Darmawan, Shirong Zheng, Byungjeon Kang, Chang Sei Kim, Doyeon Bang, Seonmin Lee, Kyu Pyo Kim, Seong Soo Kang, Kyung Mi Shim, Se Eun Kim, Seungmin Bang, Deok Ho Kim, Jong Oh Park, Eunpyo Choi

Research output: Contribution to journalArticlepeer-review

Abstract

Microrobots that can be precisely guided to target lesions have been studied for in vivo medical applications. However, existing microrobots have challenges in vivo such as biocompatibility, biodegradability, actuation module, and intra- and postoperative imaging. This study reports microrobots visualized with real-time x-ray and magnetic resonance imaging (MRI) that can be magnetically guided to tumor feeding vessels for transcatheter liver chemoembolization in vivo. The microrobots, composed of a hydrogel-enveloped porous structure and magnetic nanoparticles, enable targeted delivery of therapeutic and imaging agents via magnetic guidance from the actuation module under real-time x-ray imaging. In addition, the microrobots can be tracked using MRI as postoperative imaging and then slowly degrade over time. The in vivo validation of microrobot system–mediated chemoembolization was demonstrated in a rat liver with a tumor model. The proposed microrobot provides an advanced medical robotic platform that can overcome the limitations of existing microrobots and current liver chemoembolization.

Original languageEnglish (US)
Article numbereabq8545
JournalScience Advances
Volume8
Issue number46
DOIs
StatePublished - Nov 2022

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'Multifunctional microrobot with real-time visualization and magnetic resonance imaging for chemoembolization therapy of liver cancer'. Together they form a unique fingerprint.

Cite this