Multifocal complex glioneuronal tumor in an elderly man: An autopsy study: Case report

Jian Qiang Lu, Bernd W. Scheithauer, Pranshu Sharma, James N. Scott, Ian F. Parney, Walter Hader, Peter C. Burger, Arthur W. Clark

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


OBJECTIVE: The clinicopathological spectra of a dysembryoplastic neuroepithelial tumor (DNT) and a rosette-forming glioneuronal tumor (RGNT) are expanding. We report here the autopsy findings of a case of complex glioneuronal tumor with combined histological features of both a DNT and an RGNT. CLINICAL PRESENTATION: A 79-year-old man presented with a 1-month history of confusion and gait difficulties. A magnetic resonance imaging scan revealed obstructive hydrocephalus attributed to a mass in the posterior third ventricle. INTERVENTION: A third ventriculostomy was performed. Postoperatively, the mass remained unchanged in size for more than 14 months. Thirty-eight months after his initial manifestations, he experienced minor head trauma and was then hospitalized. Despite placement of an external ventricular drain and other supportive treatment, he deteriorated and died. A full autopsy was performed, with emphasis on the brain. The mass lesion and a few independent microfoci situated primarily around the third ventricle showed histological features of pilocytic astrocytoma with recurrent hemorrhage. Far more numerous were microfoci with histological features of a DNT, including floating neurons, as well as typical RGNT-associated, synaptophysin-positive rosettes and perivascular pseudorosettes. CONCLUSION: The advanced age of the patient, the coexisting histological features of the DNT and RGNT, and the distinctive anatomic distribution of the lesions, being centered on the third ventricle, may lend insight into the histogenetic relationship of a DNT, an RGNT, and mixed glioneuronal tumors.

Original languageEnglish (US)
Pages (from-to)E1193-E1195
Issue number6
StatePublished - Jun 2009


  • Dysembryoplastic neuroepithelial tumor
  • Multicentricity
  • Pilocytic astrocytoma
  • Rosette-forming glioneuronal tumor
  • Third ventricle

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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