Multidisciplinary treatment of medulloblastoma: A 5-year experience with the SIOP trial

Massimo A. Gerosa; Enzo di Stefano; Alessandro Olivi; Alessandro Carteri

doi:10.1159/000119972

Multidisciplinary treatment of medulloblastoma: A 5-year experience with the SIOP trial

Massimo A. Gerosa, Enzo di Stefano, Alessandro Olivi, Alessandro Carteri

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A 5-year experience of the multidisciplinary treatment of pediatric medulloblastoma with the SIOP (International Society of Pediatric Oncology) trial is presented. 33 eligible patients finally reduced to a total of 30 evaluative cases were treated with major surgical resection, extensive irradiation, and combined chemotherapy (vincristine + CCNU). The overall survival rate without recurrence was encouraging, and the actuarial survival rate is satisfactory. At follow-up controls, most of the patients showed a good performance status and a promising neurological stage. However, the problem concerning quality of life remains unsolved: Morbidity and sequelae following high-dose radiotherapy and concomitant antiblastic treatment were noticeable.

Original language	English (US)
Pages (from-to)	107-118
Number of pages	12
Journal	Pediatric Neurosurgery
Volume	8
Issue number	2
DOIs	https://doi.org/10.1159/000119972
State	Published - 1981
Externally published	Yes

Keywords

Brain neoplasms
Chemotherapy
Medulloblastoma
Radiotherapy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Surgery
Clinical Neurology

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10.1159/000119972

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title = "Multidisciplinary treatment of medulloblastoma: A 5-year experience with the SIOP trial",

abstract = "A 5-year experience of the multidisciplinary treatment of pediatric medulloblastoma with the SIOP (International Society of Pediatric Oncology) trial is presented. 33 eligible patients finally reduced to a total of 30 evaluative cases were treated with major surgical resection, extensive irradiation, and combined chemotherapy (vincristine + CCNU). The overall survival rate without recurrence was encouraging, and the actuarial survival rate is satisfactory. At follow-up controls, most of the patients showed a good performance status and a promising neurological stage. However, the problem concerning quality of life remains unsolved: Morbidity and sequelae following high-dose radiotherapy and concomitant antiblastic treatment were noticeable.",

keywords = "Brain neoplasms, Chemotherapy, Medulloblastoma, Radiotherapy",

author = "Gerosa, {Massimo A.} and {di Stefano}, Enzo and Alessandro Olivi and Alessandro Carteri",

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T2 - A 5-year experience with the SIOP trial

AU - Gerosa, Massimo A.

AU - di Stefano, Enzo

AU - Olivi, Alessandro

AU - Carteri, Alessandro

PY - 1981

Y1 - 1981

N2 - A 5-year experience of the multidisciplinary treatment of pediatric medulloblastoma with the SIOP (International Society of Pediatric Oncology) trial is presented. 33 eligible patients finally reduced to a total of 30 evaluative cases were treated with major surgical resection, extensive irradiation, and combined chemotherapy (vincristine + CCNU). The overall survival rate without recurrence was encouraging, and the actuarial survival rate is satisfactory. At follow-up controls, most of the patients showed a good performance status and a promising neurological stage. However, the problem concerning quality of life remains unsolved: Morbidity and sequelae following high-dose radiotherapy and concomitant antiblastic treatment were noticeable.

AB - A 5-year experience of the multidisciplinary treatment of pediatric medulloblastoma with the SIOP (International Society of Pediatric Oncology) trial is presented. 33 eligible patients finally reduced to a total of 30 evaluative cases were treated with major surgical resection, extensive irradiation, and combined chemotherapy (vincristine + CCNU). The overall survival rate without recurrence was encouraging, and the actuarial survival rate is satisfactory. At follow-up controls, most of the patients showed a good performance status and a promising neurological stage. However, the problem concerning quality of life remains unsolved: Morbidity and sequelae following high-dose radiotherapy and concomitant antiblastic treatment were noticeable.

KW - Brain neoplasms

KW - Chemotherapy

KW - Medulloblastoma

KW - Radiotherapy

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Multidisciplinary treatment of medulloblastoma: A 5-year experience with the SIOP trial

Abstract

Keywords

ASJC Scopus subject areas

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