Multidisciplinary care of patients with intrahepatic cholangiocarcinoma: Updates in management

Kelly J. Lafaro, David Cosgrove, Jean Francois H. Geschwind, Ihab Kamel, Joseph M. Herman, Timothy M. Pawlik

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Cholangiocarcinoma is a highly fatal primary cancer of the bile ducts which arises from malignant transformation of bile duct epithelium. While being an uncommon malignancy with an annual incidence in the United States of 5000 new cases, the incidence has been increasing over the past 30 years and comprises 3% of all gastrointestinal cancers. Cholangiocarcinoma can be classified into intrahepatic (ICC) and extrahepatic (including hilar and distal bile duct) according to its anatomic location within the biliary tree with respect to the liver. This paper reviews the management of ICC, focusing on the epidemiology, risk factors, diagnosis, and surgical and nonsurgical management.

Original languageEnglish (US)
Article number860861
JournalGastroenterology Research and Practice
StatePublished - 2015

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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