Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications

Wathsala Liyanage; Kanika Vats; Annada Rajbhandary; Danielle S.W. Benoit; Bradley L. Nilsson

doi:10.1039/c5cc03162a

Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications

Wathsala Liyanage
, Kanika Vats
, Annada Rajbhandary
, Danielle S.W. Benoit
, Bradley L. Nilsson

Research output: Contribution to journal › Article › peer-review

Abstract

Fmoc-3F-Phe-Arg-NH₂ and Fmoc-3F-Phe-Asp-OH dipeptides undergo coassembly to form two-component nanofibril hydrogels. These hydrogels support the viability and growth of NIH 3T3 fibroblast cells. The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.

Original language	English (US)
Pages (from-to)	11260-11263
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	56
DOIs	https://doi.org/10.1039/c5cc03162a
State	Published - Jul 18 2015
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c5cc03162a

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abstract = "Fmoc-3F-Phe-Arg-NH2 and Fmoc-3F-Phe-Asp-OH dipeptides undergo coassembly to form two-component nanofibril hydrogels. These hydrogels support the viability and growth of NIH 3T3 fibroblast cells. The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.",

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AU - Liyanage, Wathsala

AU - Vats, Kanika

AU - Rajbhandary, Annada

AU - Benoit, Danielle S.W.

AU - Nilsson, Bradley L.

PY - 2015/7/18

Y1 - 2015/7/18

N2 - Fmoc-3F-Phe-Arg-NH2 and Fmoc-3F-Phe-Asp-OH dipeptides undergo coassembly to form two-component nanofibril hydrogels. These hydrogels support the viability and growth of NIH 3T3 fibroblast cells. The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.

AB - Fmoc-3F-Phe-Arg-NH2 and Fmoc-3F-Phe-Asp-OH dipeptides undergo coassembly to form two-component nanofibril hydrogels. These hydrogels support the viability and growth of NIH 3T3 fibroblast cells. The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.

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UR - https://www.scopus.com/pages/publications/84933555835#tab=citedBy

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications

Abstract

ASJC Scopus subject areas

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