Multicentric parenchymal xanthogranuloma in a child: Case report and review of the literature

Maciej S. Lesniak, Michael P. Viglione, Jon Weingart, Floyd H. Gilles, Leslie N. Sutton, Robin P. Humphreys

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


OBJECTIVE AND IMPORTANCE: Xanthogranulomas of the central nervous system are rare, and asymptomatic lesions are often identified in autopsies. We report the first case of a multicentric, cystic, intraparenchymal xanthogranuloma, involving both the supra- and infratentorial compartments, in a 16-month-old girl. CLINICAL PRESENTATION: The clinical presentation consisted of a focal motor seizure in an otherwise healthy infant. INTERVENTION: Gross total removal of the infratentorial lesion was accomplished via a midline suboccipital craniotomy. CONCLUSION: Intracranial xanthogranulomas are rare, and limited experience with the diagnosis of these lesions has been reported. Although most cases are asymptomatic, this case involves a symptomatic, multicentric, intraparenchymal xanthoma in a pediatric patient. Our review of the literature provides further insights regarding the clinical, radiological, and pathological behavior of these lesions and examines the available treatment strategies.

Original languageEnglish (US)
Pages (from-to)1493-1498
Number of pages6
Issue number6
StatePublished - Dec 1 2002
Externally publishedYes


  • Intracranial
  • Multicentric
  • Pediatric
  • Seizure
  • Xanthogranuloma

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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