Multicenter and Network Trials

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Multicenter clinical trial designs offer a unique opportunity to leverage the diversity of patient populations in multiple geographic locations, share the burden of resource acquisition, and collaborate in the development of research questions and approaches. In a time of increasing globalization and rapid technological advancement, investigators are better able to conduct such projects seamlessly, benefiting investigators, sponsors, and patient populations. Regulatory agencies have embraced this shift towards the use of multicenter clinical trials in product development and have issued statements and guidance documents promoting their utility and offering best practices. Some governmental health agencies have even formed clinical trial networks to facilitate the use of multicenter clinical trials to answer a broad range of clinical questions related to a disease or disease area. This chapter will cover design considerations, data coordination, regulatory requirements, and study monitoring of multicenter clinical trials as well as how they can be conducted with a clinical trial network.

Original languageEnglish (US)
Title of host publicationPrinciples and Practice of Clinical Trials
PublisherSpringer International Publishing
Pages135-150
Number of pages16
ISBN (Electronic)9783319526362
ISBN (Print)9783319526355
DOIs
StatePublished - Jan 1 2022

Keywords

  • Clinical trial networks
  • Cooperative group clinical trials
  • Multicenter clinical trials
  • Trial consortiums

ASJC Scopus subject areas

  • General Medicine
  • General Mathematics

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