TY - JOUR
T1 - Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study
T2 - Rationale and design
AU - Nakanishi, Rine
AU - Post, Wendy S.
AU - Osawa, Kazuhiro
AU - Jayawardena, Eranthi
AU - Kim, Michael
AU - Sheidaee, Nasim
AU - Nezarat, Negin
AU - Rahmani, Sina
AU - Kim, Nicholas
AU - Hathiramani, Nicolai
AU - Susarla, Shriraj
AU - Palella, Frank
AU - Witt, Mallory
AU - Blaha, Michael J.
AU - Brown, Todd T.
AU - Kingsley, Lawrence
AU - Haberlen, Sabina A.
AU - Dailing, Christopher
AU - Budoff, Matthew J.
N1 - Publisher Copyright:
Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Background and aim The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA). Patients and methods HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time. Conclusion We describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.
AB - Background and aim The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA). Patients and methods HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time. Conclusion We describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.
KW - HIV
KW - coronary artery disease
KW - coronary computed tomographic angiography
KW - plaque progression
KW - vulnerable plaque
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U2 - 10.1097/MCA.0000000000000546
DO - 10.1097/MCA.0000000000000546
M3 - Article
C2 - 28777120
AN - SCOPUS:85038817785
SN - 0954-6928
VL - 29
SP - 23
EP - 29
JO - Coronary artery disease
JF - Coronary artery disease
IS - 1
ER -