Multi-pulse drug delivery from a resorbable polymeric microchip device

Amy C. Richards Grayson, Insung S. Choi, Betty M. Tyler, Paul P. Wang, Henry Brem, Michael J. Cima, Robert Langer

Research output: Contribution to journalArticlepeer-review

339 Scopus citations


Controlled-release drug delivery systems have many applications including treatments for hormone deficiencies and chronic pain. A biodegradable device that could provide multi-dose drug delivery would be advantageous for long-term treatment of conditions requiring pulsatile drug release. In this work, biodegradable polymeric microchips were fabricated that released four pulses of radiolabelled dextran, human growth hormone or heparin in vitro. Heparin that was released over 142 days retained on average 96 ± 12% of its bioactivity. The microchips were 1.2 cm in diameter, 480-560 μm thick and had 36 reservoirs that could each be filled with a different chemical. The devices were fabricated from poly(L-lactic acid) and had poly(D,L-lactic-co-glycolic acid) membranes of different molecular masses covering the reservoirs. A drug delivery system can be designed with the potential to release pulses of different drugs at intervals after implantation in a patient by using different molecular masses or materials for the membrane.

Original languageEnglish (US)
Pages (from-to)767-772
Number of pages6
JournalNature Materials
Issue number11
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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