@article{fb21e91f7cb140258fdaa47cb0f366fb,
title = "Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19",
abstract = "Using serial blood draws from COVID-19 patients, Su et al. present an extensive multi-omics dataset of plasma and single PBMCs covering the first week of infection following clinical diagnosis, which includes information on plasma proteins, metabolites, and on PBMC transcriptomic and surface-protein data, immune receptor sequences, secreted proteins, and electronic health record data. Their integrated analysis identifies a major immunological shift between mild and moderate infection, which includes an increase in inflammation, drop in blood nutrients, and the emergence of novel immune cell subpopulations that intensify with disease severity.",
keywords = "CITE-seq, COVID-19, immune response, infection, metabolomics, multi-omics, proteomics, single-cell RNA-seq, single-cell TCR-seq, single-cell secretome",
author = "{the ISB-Swedish COVID19 Biobanking Unit} and Yapeng Su and Daniel Chen and Dan Yuan and Christopher Lausted and Jongchan Choi and Dai, {Chengzhen L.} and Valentin Voillet and Duvvuri, {Venkata R.} and Kelsey Scherler and Pamela Troisch and Priyanka Baloni and Guangrong Qin and Brett Smith and Kornilov, {Sergey A.} and Clifford Rostomily and Alex Xu and Jing Li and Shen Dong and Alissa Rothchild and Jing Zhou and Kim Murray and Rick Edmark and Sunga Hong and Heath, {John E.} and John Earls and Rongyu Zhang and Jingyi Xie and Sarah Li and Ryan Roper and Lesley Jones and Yong Zhou and Lee Rowen and Rachel Liu and Sean Mackay and O'Mahony, {D. Shane} and Dale, {Christopher R.} and Wallick, {Julie A.} and Algren, {Heather A.} and Zager, {Michael A.} and Wei Wei and Price, {Nathan D.} and Sui Huang and Naeha Subramanian and Kai Wang and Magis, {Andrew T.} and Hadlock, {Jenn J.} and Leroy Hood and Alan Aderem and Bluestone, {Jeffrey A.} and Lanier, {Lewis L.}",
note = "Publisher Copyright: {\textcopyright} 2020",
year = "2020",
month = dec,
day = "10",
doi = "10.1016/j.cell.2020.10.037",
language = "English (US)",
volume = "183",
pages = "1479--1495.e20",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "6",
}