Multi-modal endoscopy: OCT and fluorescence

Jessica Mavadia-Shukla, Jiefeng F. Xi, Xingde D. Li

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Optical Coherence Tomography (OCT) is a recently developed and still fast evolving biomedical imaging modality based on the technique of low-coherence interferometry. OCT fills the gap between the scales of high-frequency ultrasound and confocal microscopy with an axial resolution from 1 to 15 um. OCT imaging contrast relies on tissue morphology and is governed by tissue optical absorption and scattering, and intrinsically OCT carries little molecular information. In contrast, fluorescence imaging is well known for providing tissue biochemical or molecular information. The concept of combing of OCT and fluorescence imaging has been attractive due to the fact that OCT and fluorescence imaging are complementary. Thus, in this chapter we will discuss the potential of combining OCT and single- or multi-photon fluorescence imaging endoscopically with an emphasis on system and probe design.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography
Subtitle of host publicationTechnology and Applications, Second Edition
PublisherSpringer International Publishing
Number of pages15
ISBN (Electronic)9783319064192
ISBN (Print)9783319064185
StatePublished - Jan 1 2015


  • Dual-modal endoscopy
  • Endoscope
  • Fluorescence
  • Fourier-domain OCT (FD-OCT)
  • Optical Coherence Tomography (OCT)
  • Two-photon excitation

ASJC Scopus subject areas

  • General Physics and Astronomy
  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology
  • General Engineering


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