Multi-limb acquisition of motor evoked potentials and its application in spinal cord injury

Shrivats Iyer, Anil Maybhate, Alessandro Presacco, Angelo H. All

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The motor evoked potential (MEP) is an electrical response of peripheral neuro-muscular pathways to stimulation of the motor cortex. MEPs provide objective assessment of electrical conduction through the associated neural pathways, and therefore detect disruption due to a nervous system injury such as spinal cord injury (SCI).In our studies of SCI, we developed a novel, multi-channel set-up for MEP acquisition in rat models. Unlike existing electrophysiological systems for SCI assessment, the set-up allows for multi-channel MEP acquisition from all limbs of rats and enables longitudinal monitoring of injury and treatment for in vivo models of experimental SCI.The article describes the development of the set-up and discusses its capabilities to acquire MEPs in rat models of SCI. We demonstrate its use for MEP acquisition under two types of anesthesia as well as a range of cortical stimulation parameters, identifying parameters yielding consistent and reliable MEPs.To validate our set-up, MEPs were recorded from a group of 10 rats before and after contusive SCI. Upon contusion with moderate severity (12.5. mm impact height), MEP amplitude decreased by 91.36 ± 6.03%. A corresponding decline of 93.8 ± 11.4% was seen in the motor behavioral score (BBB), a gold standard in rodent models of SCI.

Original languageEnglish (US)
Pages (from-to)210-216
Number of pages7
JournalJournal of Neuroscience Methods
Issue number2
StatePublished - Nov 30 2010
Externally publishedYes


  • Contusive spinal cord injury
  • Motor behavioral (BBB) test
  • Motor evoked potential
  • Rat model

ASJC Scopus subject areas

  • General Neuroscience


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