Multi-level regulatory interactions between NF-κB and the pluripotency factor Lin28

William T. Mills, Noor N. Nassar, Deepa Ravindra, Xinbei Li, Mollie K. Meffert

Research output: Contribution to journalReview articlepeer-review


An appreciation for the complex interactions between the NF-κB transcription factor and the Lin28 RNA binding protein/let-7 microRNA pathways has grown substantially over the past decade. Both the NF-κB and Lin28/let-7 pathways are master regulators impacting cell survival, growth and proliferation, and an understanding of how interfaces between these pathways participate in governing pluripotency, progenitor differentiation, and neuroplastic responses remains an emerging area of research. In this review, we provide a concise summary of the respective pathways and focus on the function of signaling interactions at both the transcriptional and post-transcriptional levels. Regulatory loops capable of providing both reinforcing and extinguishing feedback have been described. We highlight convergent findings in disparate biological systems and indicate future directions for investigation.

Original languageEnglish (US)
Article number2710
Pages (from-to)1-16
Number of pages16
Issue number12
StatePublished - Dec 2020


  • Let-7 microRNA
  • Lin28
  • NF-κB
  • Nervous system
  • Neurodevelopment
  • Pluripotency
  • RNA-binding protein
  • Transcription factor

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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