@article{55d524ec80ee4f7c8e440e38f3fff680,
title = "Multi-finger receptive field properties in primary somatosensory cortex: A revised account of the spatiotemporal integration functions of area 3b",
abstract = "The leading view in the somatosensory system indicates that area 3b serves as a cortical relay site that primarily encodes (cutaneous) tactile features limited to individual digits. Our recent work argues against this model by showing that area 3b cells can integrate both cutaneous and proprioceptive information from the hand. Here, we further test the validity of this model by studying multi-digit (MD) integration properties in area 3b. In contrast to the prevailing view, we show that most cells in area 3b have a receptive field (RF) that extends to multiple digits, with the size of the RF (i.e., the number of responsive digits) increasing across time. Further, we show that MD cells{\textquoteright} orientation angle preference is highly correlated across digits. Taken together, these data show that area 3b plays a larger role in generating neural representations of tactile objects, as opposed to just being a “feature detector” relay site.",
keywords = "CP: Neuroscience, RF, area 3b, cross-finger, haptics, integration, monkey, multi-digit, multi-finger, non-human primate, orientation, receptive field, somatosensory",
author = "Trzcinski, {Natalie K.} and Hsiao, {Steven S.} and Connor, {Charles E.} and Manuel Gomez-Ramirez",
note = "Funding Information: We would like to express our sincere gratitude to Justin Killebrew, William Nash, and William Quinlan (The Bills) from Johns Hopkins University for their invaluable technical assistance on the project. In addition, we would like to thank Drs. Marc Schieber and Greg DeAngelis from the University of Rochester for their insightful comments on the manuscript, and Kristjana Hysaj for helping to train and take care of the animals. This work was funded by NIH NINDS grants NS114191 (M.G.R.), NS073309 (N.K.T.), NS034086 (S.S.H.), NS018787 (S.S.H.), and NS018787-26S1 (S.S.H.). Conceived and designed the experiments: N.K.T. S.S.H. C.E.C. and M.G.R. Performed the experiments: N.K.T. and M.G.R. Analyzed the data: N.K.T. and M.G.R. Wrote the paper: N.K.T. and M.G.R. The authors declare no competing interests. This article was prepared while N.K.T. was employed at Johns Hopkins University. The opinions expressed in this article are those of the authors and do not reflect the view of National Institutes of Health, the Department of Health and Human Services, or the United States Government. Funding Information: We would like to express our sincere gratitude to Justin Killebrew, William Nash, and William Quinlan (The Bills) from Johns Hopkins University for their invaluable technical assistance on the project. In addition, we would like to thank Drs. Marc Schieber and Greg DeAngelis from the University of Rochester for their insightful comments on the manuscript, and Kristjana Hysaj for helping to train and take care of the animals. This work was funded by NIH NINDS grants NS114191 (M.G.R.), NS073309 (N.K.T.), NS034086 (S.S.H.), NS018787 (S.S.H.), and NS018787-26S1 (S.S.H.). Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
month = mar,
day = "28",
doi = "10.1016/j.celrep.2023.112176",
language = "English (US)",
volume = "42",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "3",
}