TY - JOUR
T1 - Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial
AU - Dezzutti, Charlene S.
AU - Richardson, Barbra A.
AU - Marrazzo, Jeanne M.
AU - Tugetman, Jessica
AU - Ramjee, Gita
AU - Taha, Taha
AU - Chirenje, Zvavahera M.
AU - Abdool Karim, Salim S.
AU - Hillier, Sharon L.
AU - Herold, Betsy C.
N1 - Funding Information:
Financial support. This work was supported by the Bill and Melinda Gates Foundation (grant 48293) and the Microbicide Trials Network, which is cofunded by the National Institute of Allergy and Infectious Diseases (grant UM1 AI068633), the National Institute of Child Health and Development, and the National Institute of Mental Health, all of the National Institutes of Health. Potential conflicts of interest. All authors: No reported conflicts.
PY - 2012/12/15
Y1 - 2012/12/15
N2 - The mucosal environment may impact the risk for human immunodeficiency virus type 1 (HIV-1) acquisition. Immune mediators were measured in vaginal fluid collected from HPTN 035 participants who acquired HIV-1 and from those who remained HIV-1 negative (controls). Mediator concentrations were similar in samples obtained before as compared to after HIV-1 acquisition in the 8 seroconverters. Compared with controls, seroconverters were more likely to have detectable levels of HD-2 (odds ratio [OR], 2.39; P =. 005) and greater Escherichia coli bactericidal activity (OR, 1.22; P =. 01) prior to seroconversion. E. coli bactericidal activity remained significant in a multivariable analysis (P =. 02) and may be a biomarker for HIV-1 acquisition.
AB - The mucosal environment may impact the risk for human immunodeficiency virus type 1 (HIV-1) acquisition. Immune mediators were measured in vaginal fluid collected from HPTN 035 participants who acquired HIV-1 and from those who remained HIV-1 negative (controls). Mediator concentrations were similar in samples obtained before as compared to after HIV-1 acquisition in the 8 seroconverters. Compared with controls, seroconverters were more likely to have detectable levels of HD-2 (odds ratio [OR], 2.39; P =. 005) and greater Escherichia coli bactericidal activity (OR, 1.22; P =. 01) prior to seroconversion. E. coli bactericidal activity remained significant in a multivariable analysis (P =. 02) and may be a biomarker for HIV-1 acquisition.
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U2 - 10.1093/infdis/jis555
DO - 10.1093/infdis/jis555
M3 - Article
C2 - 22966121
AN - SCOPUS:84870208216
SN - 0022-1899
VL - 206
SP - 1931
EP - 1935
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 12
ER -