Mucinous Tubular and Spindle-Cell Carcinoma of the Kidney: Clinical Features, Genomic Profiles, and Treatment Outcomes

Yasser Ged; Ying Bei Chen; Andrea Knezevic; Mark T.A. Donoghue; Maria I. Carlo; Chung Han Lee; Darren R. Feldman; Sujata Patil; A. Ari Hakimi; Paul Russo; Martin H. Voss; Robert J. Motzer

doi:10.1016/j.clgc.2019.04.006

Mucinous Tubular and Spindle-Cell Carcinoma of the Kidney: Clinical Features, Genomic Profiles, and Treatment Outcomes

Yasser Ged, Ying Bei Chen, Andrea Knezevic, Mark T.A. Donoghue, Maria I. Carlo, Chung Han Lee, Darren R. Feldman, Sujata Patil, A. Ari Hakimi, Paul Russo, Martin H. Voss, Robert J. Motzer

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We studied cancer-specifics outcomes of 25 patients with mucinous tubular and spindle-cell carcinoma of the kidney and we found that the most patients presented with localized tumor that were treated successfully with primary tumor-directed therapy. However, those with high-grade histological features were more likely to develop metastatic disease with limited responses to standard therapies.

Original language	English (US)
Pages (from-to)	268-274.e1
Journal	Clinical Genitourinary Cancer
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.clgc.2019.04.006
State	Published - Aug 2019
Externally published	Yes

Keywords

Genomics
MTSCC
Non–clear-cell renal cell carcinoma
Survival
Systemic therapy

ASJC Scopus subject areas

Oncology
Urology

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10.1016/j.clgc.2019.04.006

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Ged, Y., Chen, Y. B., Knezevic, A., Donoghue, M. T. A., Carlo, M. I., Lee, C. H., Feldman, D. R., Patil, S., Hakimi, A. A., Russo, P., Voss, M. H., & Motzer, R. J. (2019). Mucinous Tubular and Spindle-Cell Carcinoma of the Kidney: Clinical Features, Genomic Profiles, and Treatment Outcomes. Clinical Genitourinary Cancer, 17(4), 268-274.e1. https://doi.org/10.1016/j.clgc.2019.04.006

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title = "Mucinous Tubular and Spindle-Cell Carcinoma of the Kidney: Clinical Features, Genomic Profiles, and Treatment Outcomes",

abstract = "We studied cancer-specifics outcomes of 25 patients with mucinous tubular and spindle-cell carcinoma of the kidney and we found that the most patients presented with localized tumor that were treated successfully with primary tumor-directed therapy. However, those with high-grade histological features were more likely to develop metastatic disease with limited responses to standard therapies.",

keywords = "Genomics, MTSCC, Non–clear-cell renal cell carcinoma, Survival, Systemic therapy",

author = "Yasser Ged and Chen, {Ying Bei} and Andrea Knezevic and Donoghue, {Mark T.A.} and Carlo, {Maria I.} and Lee, {Chung Han} and Feldman, {Darren R.} and Sujata Patil and Hakimi, {A. Ari} and Paul Russo and Voss, {Martin H.} and Motzer, {Robert J.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = aug,

doi = "10.1016/j.clgc.2019.04.006",

language = "English (US)",

volume = "17",

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T2 - Clinical Features, Genomic Profiles, and Treatment Outcomes

AU - Ged, Yasser

AU - Chen, Ying Bei

AU - Knezevic, Andrea

AU - Donoghue, Mark T.A.

AU - Carlo, Maria I.

AU - Lee, Chung Han

AU - Feldman, Darren R.

AU - Patil, Sujata

AU - Hakimi, A. Ari

AU - Russo, Paul

AU - Voss, Martin H.

AU - Motzer, Robert J.

PY - 2019/8

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N2 - We studied cancer-specifics outcomes of 25 patients with mucinous tubular and spindle-cell carcinoma of the kidney and we found that the most patients presented with localized tumor that were treated successfully with primary tumor-directed therapy. However, those with high-grade histological features were more likely to develop metastatic disease with limited responses to standard therapies.

AB - We studied cancer-specifics outcomes of 25 patients with mucinous tubular and spindle-cell carcinoma of the kidney and we found that the most patients presented with localized tumor that were treated successfully with primary tumor-directed therapy. However, those with high-grade histological features were more likely to develop metastatic disease with limited responses to standard therapies.

KW - Genomics

KW - MTSCC

KW - Non–clear-cell renal cell carcinoma

KW - Survival

KW - Systemic therapy

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SP - 268-274.e1

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ER -

Mucinous Tubular and Spindle-Cell Carcinoma of the Kidney: Clinical Features, Genomic Profiles, and Treatment Outcomes

Abstract

Keywords

ASJC Scopus subject areas

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