MRNA Vaccine-Elicited Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Specific T Cells Persist at 6 Months and Recognize the Delta Variant

Bezawit A. Woldemeskel; Caroline C. Garliss; Joel N. Blankson

doi:10.1093/cid/ciab915

MRNA Vaccine-Elicited Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Specific T Cells Persist at 6 Months and Recognize the Delta Variant

Bezawit A. Woldemeskel
, Caroline C. Garliss
, Joel N. Blankson

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Little is known about the decay kinetics of coronavirus disease 2019 vaccine-elicited severe acute respiratory syndrome coronavirus 2-specific T cells. In this study we show a modest decline in the frequency of these T cells at 6 months and demonstrate robust expansion in response to antigen and recognition of spike peptides from the Delta variant.

Original language	English (US)
Pages (from-to)	E898-E901
Journal	Clinical Infectious Diseases
Volume	75
Issue number	1
DOIs	https://doi.org/10.1093/cid/ciab915
State	Published - Jul 1 2022

Keywords

COVID
Delta variant
SARS-CoV-2
T cells
mRNA vaccines

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1093/cid/ciab915

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abstract = "Little is known about the decay kinetics of coronavirus disease 2019 vaccine-elicited severe acute respiratory syndrome coronavirus 2-specific T cells. In this study we show a modest decline in the frequency of these T cells at 6 months and demonstrate robust expansion in response to antigen and recognition of spike peptides from the Delta variant.",

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AU - Blankson, Joel N.

PY - 2022/7/1

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KW - Delta variant

KW - SARS-CoV-2

KW - T cells

KW - mRNA vaccines

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MRNA Vaccine-Elicited Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Specific T Cells Persist at 6 Months and Recognize the Delta Variant

Abstract

Keywords

ASJC Scopus subject areas

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