MRI of bone marrow edema-like signal in the pathogenesis of subchondral cysts

J. A. Carrino, J. Blum, J. A. Parellada, M. E. Schweitzer, W. B. Morrison

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


Objective: To determine if a relationship exists between bone marrow edema-like signal and subchondral cysts on magnetic resonance imaging (MRI). Design: Retrospective cohort of 32 patients with two sequential knee MRI. Patients with acute trauma, infection, neoplasm, or osteonecrosis were excluded. The degree of osteoarthritis was assessed using an adaptation of the Baltimore Longitudinal Study of Aging (BLSA) scale. Initial and follow-up exams were reviewed for presence, location, size and changes of marrow edema-like signal, subarticular cysts and cartilage abnormality. All locations in the knee were aggregated for analysis with descriptive statistics. Results: The mean time interval between exams was 17.52 months (range 2.1-40.1 months). There were 23 cysts: 11 (47.8%) new, 6 (26.1%) increased size, 1 (4.4%) decreased size, and 5 (21.7%) no change in pre-existing lesions. Cysts always arose from regions of marrow edema-like signal. There were 68 subarticular areas of marrow edema-like signal: 16 (23.5%) new, 23 (33.8%) increased size, 17 (25%) decreased size, 11 (16.2%) resolved and 1 (1.5%) no change in pre-existing lesion. Marrow edema-like signal size always changed with cyst development: increased in 6/11 (54.5%), decreased in 2/11 (18.1%) and resolved in 3/11 (27.2%). Change in cyst size was always accompanied by a change in edema-like signal size. An MRI visible cartilage abnormality was adjacent to 87% (20/23) of cysts. The mean BLSA score changed from 2.6 to 3.6 indicating an overall progression of osteoarthritis. Conclusion: Subchondral cysts develop in pre-existing regions of subchondral bone marrow edema-like signal.

Original languageEnglish (US)
Pages (from-to)1081-1085
Number of pages5
JournalOsteoarthritis and Cartilage
Issue number10
StatePublished - Oct 2006
Externally publishedYes


  • Bone marrow
  • Magnetic resonance imaging (MRI)
  • Osteoarthritis
  • Subchondral cyst

ASJC Scopus subject areas

  • Rheumatology
  • Biomedical Engineering
  • Orthopedics and Sports Medicine


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