MRI measurement of brain iron in patients with restless legs syndrome

Richard P. Allen; P. B. Barker; F. Wehrl; H. K. Song; C. J. Earley

doi:10.1212/WNL.56.2.263

MRI measurement of brain iron in patients with restless legs syndrome

Richard P. Allen, P. B. Barker, F. Wehrl, H. K. Song, C. J. Earley

School of Medicine

Research output: Contribution to journal › Article › peer-review

451 Scopus citations

Abstract

Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior CSF study. Using a special MRI measurement (R₂′), the authors assessed regional brain iron concentrations in 10 subjects (five with RLS, five controls). R₂′ was significantly decreased in the substantia nigra, and somewhat less significantly in the putamen, both in proportion to RLS severity. The results show the potential utility of this MRI measurement, and also indicate that brain iron insufficiency may occur in patients with RLS in some brain regions.

Original language	English (US)
Pages (from-to)	263-265
Number of pages	3
Journal	Neurology
Volume	56
Issue number	2
DOIs	https://doi.org/10.1212/WNL.56.2.263
State	Published - Jan 23 2001

ASJC Scopus subject areas

Clinical Neurology

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10.1212/WNL.56.2.263

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AU - Barker, P. B.

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AU - Song, H. K.

AU - Earley, C. J.

PY - 2001/1/23

Y1 - 2001/1/23

N2 - Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior CSF study. Using a special MRI measurement (R2′), the authors assessed regional brain iron concentrations in 10 subjects (five with RLS, five controls). R2′ was significantly decreased in the substantia nigra, and somewhat less significantly in the putamen, both in proportion to RLS severity. The results show the potential utility of this MRI measurement, and also indicate that brain iron insufficiency may occur in patients with RLS in some brain regions.

AB - Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior CSF study. Using a special MRI measurement (R2′), the authors assessed regional brain iron concentrations in 10 subjects (five with RLS, five controls). R2′ was significantly decreased in the substantia nigra, and somewhat less significantly in the putamen, both in proportion to RLS severity. The results show the potential utility of this MRI measurement, and also indicate that brain iron insufficiency may occur in patients with RLS in some brain regions.

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MRI measurement of brain iron in patients with restless legs syndrome

Abstract

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