TY - JOUR
T1 - MRI criteria for the diagnosis of multiple sclerosis
T2 - MAGNIMS consensus guidelines
AU - Filippi, Massimo
AU - Rocca, Maria A.
AU - Ciccarelli, Olga
AU - De Stefano, Nicola
AU - Evangelou, Nikos
AU - Kappos, Ludwig
AU - Rovira, Alex
AU - Sastre-Garriga, Jaume
AU - Tintorè, Mar
AU - Frederiksen, Jette L.
AU - Gasperini, Claudio
AU - Palace, Jacqueline
AU - Reich, Daniel S.
AU - Banwell, Brenda
AU - Montalban, Xavier
AU - Barkhof, Frederik
N1 - Funding Information:
The workshop that formed the basis of this Review was supported by an unrestricted educational grant from Novartis. The funding source had no role in the preparation of this article. We are very grateful to Douglas Arnold (Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC, Canada) for his fruitful discussion during the meeting and his subsequent thoughtful comments on the manuscript. We also thank Martina Absinta (Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy) and Pascal Sati (Translational Neuroradiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA) for providing figures 3 and 4 . LK has received research grants from the Swiss MS Society, the Swiss National Research Foundation, and the European Union. JP has received research grants from the Multiple Sclerosis Society UK, and the Guthy-Jackson Foundation. FB receives research support from Neugrid4you (FP7 European committee) and the Dutch Foundation for MS Research—centre grant 2010–14.
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016
Y1 - 2016
N2 - In patients presenting with a clinically isolated syndrome, MRI can support and substitute clinical information in the diagnosis of multiple sclerosis by showing disease dissemination in space and time and by helping to exclude disorders that can mimic multiple sclerosis. MRI criteria were first included in the diagnostic work-up for multiple sclerosis in 2001, and since then several modifications to the criteria have been proposed in an attempt to simplify lesion-count models for showing disease dissemination in space, change the timing of MRI scanning to show dissemination in time, and increase the value of spinal cord imaging. Since the last update of these criteria, new data on the use of MRI to establish dissemination in space and time have become available, and MRI technology has improved. State-of-the-art MRI findings in these patients were discussed in a MAGNIMS workshop, the goal of which was to provide an evidence-based and expert-opinion consensus on proposed modifications to MRI criteria for the diagnosis of multiple sclerosis.
AB - In patients presenting with a clinically isolated syndrome, MRI can support and substitute clinical information in the diagnosis of multiple sclerosis by showing disease dissemination in space and time and by helping to exclude disorders that can mimic multiple sclerosis. MRI criteria were first included in the diagnostic work-up for multiple sclerosis in 2001, and since then several modifications to the criteria have been proposed in an attempt to simplify lesion-count models for showing disease dissemination in space, change the timing of MRI scanning to show dissemination in time, and increase the value of spinal cord imaging. Since the last update of these criteria, new data on the use of MRI to establish dissemination in space and time have become available, and MRI technology has improved. State-of-the-art MRI findings in these patients were discussed in a MAGNIMS workshop, the goal of which was to provide an evidence-based and expert-opinion consensus on proposed modifications to MRI criteria for the diagnosis of multiple sclerosis.
UR - http://www.scopus.com/inward/record.url?scp=84957812890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957812890&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(15)00393-2
DO - 10.1016/S1474-4422(15)00393-2
M3 - Review article
C2 - 26822746
AN - SCOPUS:84957812890
SN - 1474-4422
VL - 15
SP - 292
EP - 303
JO - The Lancet Neurology
JF - The Lancet Neurology
IS - 3
ER -