TY - JOUR
T1 - MRI-Conditional Eccentric-Tube Injection Needle
T2 - Design, Fabrication, and Animal Trial
AU - Gunderman, Anthony L.
AU - Schmidt, Ehud J.
AU - Xiao, Qingyu
AU - Tokuda, Junichi
AU - Seethamraju, Ravi T.
AU - Neri, Luca
AU - Halperin, Henry R.
AU - Kut, Carmen
AU - Viswanathan, Akila N.
AU - Morcos, Marc
AU - Chen, Yue
N1 - Publisher Copyright:
© 1996-2012 IEEE.
PY - 2023/8/1
Y1 - 2023/8/1
N2 - Effective radiation therapy aims to maximize the radiation dose delivered to the tumor, while minimizing damage to the surrounding healthy tissues, which can be a challenging task when the tissue-tumor space is small. To eliminate the damage to healthy tissue, it is now possible to inject biocompatible hydrogels between cancerous targets and surrounding tissues to create a spacer pocket. Conventional methods have limitations in poor target visualization and device tracking. In this article, we leverage our MR-tracking technique to develop a novel injection needle for hydrogel spacer deployment. Herein, we present the working principle and fabrication method, followed by benchtop validation in an agar phantom, and magnetic resonance imaging (MRI)-guided validation in tissue-mimic prostate phantom and sexually mature female swine. Animal trials indicated that the spacer pockets in the rectovaginal septum can be accurately visualized on T2-weighted MRI. The experimental results showed that the vaginal-rectal spacing was successfully increased by 12 ± bm2 mm anterior-posterior.
AB - Effective radiation therapy aims to maximize the radiation dose delivered to the tumor, while minimizing damage to the surrounding healthy tissues, which can be a challenging task when the tissue-tumor space is small. To eliminate the damage to healthy tissue, it is now possible to inject biocompatible hydrogels between cancerous targets and surrounding tissues to create a spacer pocket. Conventional methods have limitations in poor target visualization and device tracking. In this article, we leverage our MR-tracking technique to develop a novel injection needle for hydrogel spacer deployment. Herein, we present the working principle and fabrication method, followed by benchtop validation in an agar phantom, and magnetic resonance imaging (MRI)-guided validation in tissue-mimic prostate phantom and sexually mature female swine. Animal trials indicated that the spacer pockets in the rectovaginal septum can be accurately visualized on T2-weighted MRI. The experimental results showed that the vaginal-rectal spacing was successfully increased by 12 ± bm2 mm anterior-posterior.
KW - Active tracking
KW - injection needle
KW - magnetic resonance imaging (MRI)-conditional
KW - radiation therapy
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U2 - 10.1109/TMECH.2022.3232546
DO - 10.1109/TMECH.2022.3232546
M3 - Article
AN - SCOPUS:85147284051
SN - 1083-4435
VL - 28
SP - 2405
EP - 2410
JO - IEEE/ASME Transactions on Mechatronics
JF - IEEE/ASME Transactions on Mechatronics
IS - 4
ER -