MRI and MRS of intact perfused cancer cell metabolism, invasion, and stromal cell interactions

Marie France Penet, Tariq Shah, Flonne Wildes, Balaji Krishnamachary, Santosh K. Bharti, Jesus Pacheco-Torres, Dmitri Artemov, Zaver M. Bhujwalla

Research output: Contribution to journalReview articlepeer-review


Because of the spatial and temporal heterogeneities of cancers, technologies to investigate cancer cells and the consequences of their interactions with abnormal physiological environments, such as hypoxia and acidic extracellular pH, with stromal cells, and with the extracellular matrix, under controlled conditions, are valuable to gain insights into the functioning of cancers. These insights can lead to an understanding of why cancers invade and metastasize, and identify effective treatment strategies. Here we have provided an overview of the applications of MRI/MRS/MRSI to investigate intact perfused cancer cells, their metabolism and invasion, and their interactions with stromal cells and the extracellular matrix.

Original languageEnglish (US)
Article numbere4053
JournalNMR in biomedicine
Issue number10
StatePublished - Oct 1 2019


  • hypoxia
  • intact cancer cells
  • invasion
  • metabolism
  • perfusion
  • stromal cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy


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